CDD/SPARCLE: the conserved domain database in 2020

被引：2081

作者：

Lu, Shennan ^{[1
]}

Wang, Jiyao ^{[1
]}

Chitsaz, Farideh ^{[1
]}

Derbyshire, Myra K. ^{[1
]}

Geer, Renata C. ^{[1
]}

Gonzales, Noreen R. ^{[1
]}

Gwadz, Marc ^{[1
]}

Hurwitz, David, I ^{[1
]}

Marchler, Gabriele H. ^{[1
]}

Song, James S. ^{[1
]}

Thanki, Narmada ^{[1
]}

Yamashita, Roxanne A. ^{[1
]}

Yang, Mingzhang ^{[1
]}

Zhang, Dachuan ^{[1
]}

Zheng, Chanjuan ^{[1
]}

Lanczycki, Christopher J. ^{[1
]}

Marchler-Bauer, Aron ^{[1
]}

机构：

[1] Natl Ctr Biotechnol Informat, Natl Lib Med, NIH, Bldg 38 A,Room 8N805,8600 Rockville Pike, Bethesda, MD 20894 USA

来源：

NUCLEIC ACIDS RESEARCH | 2020年 / 48卷 / D1期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/nar/gkz991

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As NLM's Conserved Domain Database (CDD) enters its 20th year of operations as a publicly available resource, CDD curation staff continues to develop hierarchical classifications of widely distributed protein domain families, and to record conserved sites associated with molecular function, so that they can be mapped onto user queries in support of hypothesis-driven biomolecular research. CDD offers both an archive of pre-computed domain annotations as well as live search services for both single protein or nucleotide queries and larger sets of protein query sequences. CDD staff has continued to characterize protein families via conserved domain architectures and has built up a significant corpus of curated domain architectures in support of naming bacterial proteins in RefSeq. These architecture definitions are available via SPARCLE, the Subfamily Protein Architecture Labeling Engine.

引用

页码：D265 / D268

页数：4

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