Luteolin inhibits FcεRI- and MRGPRX2-mediated mast cell activation by regulating calcium signaling pathways

被引：15

作者：

Hao, Yong ^{[1
,2
]}

Che, Delu ^{[1
]}

Yu, Yanqin ^{[3
]}

Liu, Lixia ^{[4
]}

Mi, Shuhong ^{[5
]}

Zhang, Yang ^{[5
]}

Hao, Jinqi ^{[6
]}

Li, Wei ^{[5
]}

Ji, Musi ^{[2
]}

Geng, Songmei ^{[1
]}

Shi, Jihai ^{[5
]}

机构：

[1] Xi An Jiao Tong Univ, Northwest Hosp, Dept Dermatol, Affiliated Hosp 2, 157 Xi Wu Rd, Xian 710004, Shaanxi, Peoples R China

[2] Inner Mongolia Univ Sci & Technol, Affiliated Hosp 2, Dept Dermatol, Baotou Med Coll, Baotou, Peoples R China

[3] Inner Mongolia Univ Sci & Technol, Affiliated Hosp 1, Res Ctr Clin Epidemiol, Baotou Med Coll, Baotou, Peoples R China

[4] Bayannur Hosp, Dept Dermatol, Bayannur, Peoples R China

[5] Inner Mongolia Univ Sci & Technol, Affiliated Hosp 1, Dept Dermatol, Baotou Med Coll, 41 Linyin Rd, Baotou 014010, Inner Mongolia, Peoples R China

[6] Inner Mongolia Univ Sci & Technol, Baotou Med Coll, Sch Publ Hlth, Baotou, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2022年 / 36卷 / 05期

基金：

中国国家自然科学基金;

关键词：

anaphylactic reactions; fc epsilon RI; Luteolin; mast cells; MRGPRX2; X2;

D O I：

10.1002/ptr.7447

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Luteolin is a flavonoid found in many fruits, vegetables, and herbs. The antiinflammatory effects of luteolin have been reported. In this study, the effect of luteolin on allergic diseases and the underlying molecular mechanism were investigated. We found that luteolin inhibits Fc epsilon RI (Fc epsilon RI)- and Mas-related G protein-coupled receptor X2 (MRGPRX2)-mediated mast cells (MCs) activation, including degranulation and release of cytokines in vitro. Moreover, luteolin reduces the degree of swelling and Evans blue exudation of mice paw in a dose-dependent manner. The concentrations of histamine, TNF-alpha, MCP-1, IL-8, and IL-13 in mice serum are also decreased by luteolin administration. Our study reveals that luteolin can inhibit Fc epsilon RI- and MRGPRX2-mediated allergic responses in vivo and in vitro, and our results discover luteolin inhibited mast cells mediated anaphylactic reaction by inhibiting the phosphorylation level of PLC gamma.

引用

页码：2197 / 2206

页数：10

共 24 条

[1] Mast cell activation syndromes [J].

Akin, Cem .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (02) :349-355

[2]

Ali Hydar, 2016, J Immunobiol, V1

[3] Clinical significance of serum MRGPRX2 as a new biomarker in allergic asthma [J].

An, Jin ;

Lee, Ji-Hyang ;

Won, Ha-Kyeong ;

Kang, Yewon ;

Song, Woo-Jung ;

Kwon, Hyouk-Soo ;

Cho, You Sook ;

Moon, Hee-Bom ;

Kim, Tae-Bum .

ALLERGY, 2020, 75 (04) :959-962

[4]

Azimi Ehsan, 2017, Itch (Phila), V2, DOI 10.1097/itx.0000000000000005

[5] Allergic FcεRI- and pseudo-allergic MRGPRX2-triggered mast cell activation routes are independent and inversely regulated by SCF [J].

Babina, M. ;

Guhl, S. ;

Artuc, M. ;

Zuberbier, T. .

ALLERGY, 2018, 73 (01) :256-260

[6] The role of mast cells in autoinflammation [J].

Bonnekoh, Hanna ;

Scheffel, Jorg ;

Kambe, Naotomo ;

Krause, Karoline .

IMMUNOLOGICAL REVIEWS, 2018, 282 (01) :265-275

[7] Mivacurium induce mast cell activation and pseudo-allergic reactions via MAS-related G protein coupled receptor-X2 [J].

Che, Delu ;

Wang, Jue ;

Ding, Yuanyuan ;

Liv, Rui ;

Cao, Jiao ;

Zhang, Yongjing ;

Hou, Yajing ;

An, Hongli ;

Gao, Zijun ;

Zhang, Tao .

CELLULAR IMMUNOLOGY, 2018, 332 :121-128

[8] Dehydroandrographolide inhibits IgE-mediated anaphylactic reactions via calcium signaling pathway [J].

Che, Deu ;

Hou, Yajing ;

Zeng, Yingnan ;

Li, Chaomei ;

Zhang, Yongjing ;

Wei, Di ;

Hu, Shiling ;

Liu, Rui ;

An, Hongli ;

Wang, Yajun ;

Zhang, Tao .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 366 :46-53

[9] Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria [J].

Fujisawa, Daisuke ;

Kashiwakura, Jun-ichi ;

Kita, Hirohito ;

Kikukawa, Yusuke ;

Fujitani, Yasushi ;

Sasaki-Sakamoto, Tomomi ;

Kuroda, Kazumichi ;

Nunomura, Satoshi ;

Hayama, Koremasa ;

Terui, Tadashi ;

Ra, Chisei ;

Okayama, Yoshimichi .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 134 (03) :622-+

[10] Different activation signals induce distinct mast cell degranulation strategies [J].

Gaudenzio, Nicolas ;

Sibilano, Riccardo ;

Marichal, Thomas ;

Starkl, Philipp ;

Reber, Laurent L. ;

Cenac, Nicolas ;

McNeil, Benjamin D. ;

Dong, Xinzhong ;

Hernandez, Joseph D. ;

Sagi-Eisenberg, Ronit ;

Hammel, Ilan ;

Roers, Axel ;

Valitutti, Salvatore ;

Tsai, Mindy ;

Espinosa, Eric ;

Galli, Stephen J. .

JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (10) :3981-3998

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