Photochemical behaviour of propranolol in environmental waters: the hydroxylated photoproducts

被引：9

作者：

Piram, Anne ^{[1
]}

Faure, Rene ^{[1
]}

Chermette, Henry ^{[1
]}

Bordes, Claire ^{[1
]}

Herbreteau, Bernard ^{[1
]}

Salvador, Arnaud ^{[1
]}

机构：

[1] Univ Lyon 1, Analyt Sci Lab, CNRS, CPE,UMR 5180, F-69622 Villeurbanne, France

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY | 2012年 / 92卷 / 01期

关键词：

propranolol; water treatment plant; liquid chromatography; mass spectrometry; photodegradation; hydroxylated photoproducts; RECEPTOR-BLOCKING PHARMACEUTICALS; DENSITY-FUNCTIONAL THEORY; BETA-BLOCKERS; RISK-ASSESSMENT; PHOTODEGRADATION; DEGRADATION; PHOTOLYSIS; EFFLUENTS; PRODUCTS; RESIDUES;

D O I：

10.1080/03067319.2010.497920

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The UV irradiation of propranolol, one of the beta-blockers currently used in cardiac medicine, was studied. During irradiation, the samples were analysed by LC/MS/MS, using a Waters Symmetry C-18 (3.5 mu m 150 x 2.1 mm) column. The main photoproducts were identified from mono-, di- and tri-hydroxylation of the propranolol naphthalenic skeleton. Hydroxyl group positions were predicted by means of theoretical calculations. Partial charge calculations of the propranolol atoms predicted the formation of four mono-hydroxylated compounds, two of them being the most probable. From these two compounds, three di-hydroxylated compounds were predicted. Then the calculations from the two most probable di-hydroxylated compounds were used to propose three tri-hydroxylated propranolol compounds. It was found that the same hydroxylated photoproducts are formed in pure water and in treatment plant waste water.

引用

页码：96 / 109

页数：14

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