Methods for Detection of Circulating Tumour Cells and Their Clinical Value in Cancer Patients

被引：3
作者：
Mikulova, V. [1 ,2 ,3 ]
Kolostova, K. [4 ]
Zima, T. [1 ,2 ,3 ]
机构：
[1] Charles Univ Prague, Lab Clin Immunol & Allergol, Inst Clin Biochem, Fac Med 1, Prague 12111 2, Czech Republic
[2] Charles Univ Prague, Diagnost Lab, Fac Med 1, Prague 12111 2, Czech Republic
[3] Gen Univ Hosp, Prague 12111 2, Czech Republic
[4] Charles Univ Prague, Dept Tumour Biol, Fac Med 3, Prague 12111 2, Czech Republic
来源：
FOLIA BIOLOGICA | 2011年 / 57卷 / 04期
关键词：
circulating tumour cells; disseminated tumour cells; clinical value; detection methods; breast cancer; CYTOKERATIN-POSITIVE CELLS; POLYMERASE CHAIN-REACTION; METASTATIC BREAST-CANCER; BONE-MARROW; PERIPHERAL-BLOOD; RT-PCR; EPITHELIAL-CELLS; MOLECULAR CHARACTERIZATION; IMMUNOMAGNETIC ENRICHMENT; ENDOTHELIAL-CELLS;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Currently available analytical methods enable identification, detection and characterization of circulating tumour cells in the peripheral blood and disseminated tumour cells in the bone marrow of breast cancer patients. About 0.01 % of the circulating tumour cells observed in the blood are able to form metastases. Therefore, they could be used for estimation of the risk for metastatic relapse, as a diagnostic tool for patient stratification, early determination of the therapy failure, or potential risk of resistance to the given therapeutic intervention. New therapeutic molecular targets could be identified for management of cancer patients using circulating tumour cell detection. The following review summarizes introduced methods of circulating tumour cell detection and their possible application in clinics.
引用
收藏
页码：151 / 161
页数：11
相关论文
共 49 条
[1]   Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients [J].
Aktas, Bahriye ;
Tewes, Mitra ;
Fehm, Tanja ;
Hauch, Siegfried ;
Kimmig, Rainer ;
Kasimir-Bauer, Sabine .
BREAST CANCER RESEARCH, 2009, 11 (04)
[2]   Prospective identification of tumorigenic breast cancer cells [J].
Al-Hajj, M ;
Wicha, MS ;
Benito-Hernandez, A ;
Morrison, SJ ;
Clarke, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988
[3]   Full-length cytokeratin-19 is released by human tumor cells: a potential role in metastatic progression of breast cancer [J].
Alix-Panabieres, Catherine ;
Vendrell, Jean-Pierre ;
Slijper, Monique ;
Pelle, Olivier ;
Barbotte, Eric ;
Mercier, Gregoire ;
Jacot, William ;
Fabbro, Michel ;
Pantel, Klaus .
BREAST CANCER RESEARCH, 2009, 11 (03)
[4]  
Baker MK, 2003, CLIN CANCER RES, V9, P4865
[5]  
Bauer KD, 2000, CLIN CANCER RES, V6, P3552
[6]   Modeling the relationship between circulating tumour cells number and prognosis of metastatic breast cancer [J].
Botteri, Edoardo ;
Sandri, Maria Teresa ;
Bagnardi, Vincenzo ;
Munzone, Elisabetta ;
Zorzino, Laura ;
Rotmensz, Nicole ;
Casadio, Chiara ;
Cassatella, Maria Cristina ;
Esposito, Angela ;
Curigliano, Giuseppe ;
Salvatici, Michela ;
Verri, Elena ;
Adamoli, Laura ;
Goldhirsch, Aron ;
Nole, Franco .
BREAST CANCER RESEARCH AND TREATMENT, 2010, 122 (01) :211-217
[7]   Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. [J].
Braun, S ;
Pantel, K ;
Muller, P ;
Janni, W ;
Hepp, F ;
Kentenich, CRM ;
Gastroph, S ;
Wischnik, A ;
Dimpfl, T ;
Kindermann, G ;
Riethmuller, G ;
Schlimok, G .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (08) :525-533
[8]  
Braun S, 1999, INT J CANCER, V84, P1, DOI 10.1002/(SICI)1097-0215(19990219)84:1<1::AID-IJC1>3.0.CO
[9]  
2-A
[10]   Prognostic significance of occult lymph node metastases in node-negative breast cancer [J].
Clare, SE ;
Sener, SF ;
Wilkens, W ;
Goldschmidt, R ;
Merkel, D ;
Winchester, DJ .
ANNALS OF SURGICAL ONCOLOGY, 1997, 4 (06) :447-451
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