Resting sympathetic outflow does not predict the morning blood pressure surge in hypertension

Objective The blood pressure (BP) rise on awakening (morning surge) might be a predictor of hypertension-related cardiovascular complications. Previous studies suggest that the autonomic nervous system may contribute to the early morning BP increase. We tested the hypothesis that resting sympathetic outflow [assessed by direct measures of intraneural sympathetic nerve activity (SNA)] may help predict the morning BP surge in hypertension. Methods We measured muscle SNA (MSNA), heart rate (HR) and BP during undisturbed supine rest in 68 newly diagnosed untreated hypertensive patients (53 men and 15 women, age 40 +/- 3 years, BMI 27 +/- 1 kg/m(2), mean +/- SEM). The morning BP surge was defined as the difference between the morning BP and the pre-awake BP. Results SBP averaged 143 +/- 3mmHg for daytime and 126 +/- 2mmHg for night-time. Mean HR was 81 +/- 2 beats/min for daytime and 69 +/- 2 beats/min for night-time. Average MSNA was 32 +/- 2 bursts/min., SBP morning surge 19 +/- 2mmHg and HR morning surge 14 +/- 2 beats/min. In univariate analysis, MSNA correlated with daytime SBP (r=0.28, P=0.02); night-time SBP (r=0.26, P=0.03); daytime HR (r=0.28, P=0.02); and night-time HR (r=0.26, P=0.03). Multivariate analysis, taking into consideration age, BMI and sex, revealed that MSNA was independently related to both daytime (P=0.006) and night-time HR (P=0.02), but not to ambulatory SBP. The morning surge of SBP and HR was not related to MSNA (r=0.01 and r=0.07, respectively, P=NS). Conclusion In patients with essential hypertension, MSNA is related to both daytime and night-time HR, but not to the morning BP surge. J Hypertens 29: 2381-2386 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.