A HPLC validated assay of paclitaxel's related impurities in pharmaceutical forms containing Cremophor® EL

被引：14

作者：

Ciutaru, D

Badea, I

Lazar, L

Nicolescu, D

Tudose, A

机构：

[1] Univ Bucharest, Dept Analyt Chem, Bucharest 70346, Romania

[2] Sindan Pharmaceut Co, Bucharest 78168, Romania

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2004年 / 34卷 / 03期

关键词：

paclitaxel; related impurities; Cremophor (R) EL; HPLC;

D O I：

10.1016/S0731-7085(03)00632-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A HPLC method has been developed for the determination of the paclitaxel's related impurities in pharmaceutical forms. This method ensures the rapid determination of related impurities in the presence of polyoxyl castor oil-the main constituent of paclitaxel's clinical formulation vehicle. The method is simple and does not require any preliminary treatment of the sample. The method was fully validated. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：493 / 499

页数：7

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