Fe NPs and MWCNTs based electrode as FIA detector for determination of amino acids in hypothalamus microdialysis fluids

被引:4
作者
Wang, Jing [1 ]
Liu, Xueying [1 ]
Wang, Yiting [1 ]
Yu, Lei [1 ]
Peng, Hui [1 ]
Zhu, Jian-Zhong [1 ]
机构
[1] East China Normal Univ, Sch Chem & Mol Engn, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China
基金
中国国家自然科学基金;
关键词
Amino acids; Fe nanoparticles; Multiwall carbon nanotubes; Amperometric electrode detector; Hypothalamus dialysis fluid; ELECTROCATALYTIC OXIDATION; CARBON NANOTUBES; SENSITIVE DETECTION; GLYCINE; SENSOR; ADSORPTION; CYSTEINE; LYSINE; ALPHA; OXIDE;
D O I
10.1016/j.snb.2016.07.115
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
An amperometric electrode based on multiwall carbon nanotubes (MWCNTs) and Fe nanoparticles (NPs) has been successfully fabricated. The electrode combined with Flow Injection Analysis (FIA) exhibits linear response in the concentration range of 0.1-12 mu M and the sensitivity of 30.0 nA mu M-1 for most of amino acids, confirming good complexation of amino acids (AAs) with Fe NPs on the modified electrode. The determination of 17 amino acids in the hypothalamus microdialysis fluids of guinea pigs, illustrates that it is a powerful tool to investigate physiology and pathology mechanisms. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:834 / 841
页数:8
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