Clinical Features and Efficacy of Escitalopram Treatment for Geriatric Depression

被引:12
作者
Chen, Y-M [1 ,2 ]
Huang, X-M [2 ]
Thompson, R. [2 ]
Zhao, Y-B [1 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Neurol, Shanghai 200080, Peoples R China
[2] Sanford Burnham Med Res Inst, Del E Webb Ctr Neurosci Aging & Stem Cell Res, La Jolla, CA USA
关键词
ESCITALOPRAM; SELECTIVE SEROTONIN REUPTAKE INHIBITOR (SSRI); GERIATRIC DEPRESSION; RANDOMIZED CONTROLLED TRIAL; EFFICACY; SAFETY; DIAGNOSIS; DISORDER;
D O I
10.1177/147323001103900540
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This study investigated the psychological characteristics and clinical features of 55 patients with geriatric depression, and evaluated the efficacy and safety of escitalopram in the treatment of geriatric depression, in a randomized controlled trial. Fifty-five patients with geriatric depression were randomly assigned to receive 8 weeks of escitalopram 10 mg, daily, orally (n = 29) or placebo (n = 26). At baseline, these patients had significantly higher neuroticism and psychoticism scores on the Eysenck Personality Questionnaire - Adult scale than Chinese population norms. General Severity Index scores and the mean values of the nine subscales of the Symptom Checklist-90 - Revised scale were also significantly higher in these patients than in Chinese population norms. The response rate to escitalopram after 8 weeks' treatment was 74.1% (20/27 patients). Adverse reactions included nausea, dry mouth and dizziness. In conclusion, depressed geriatric patients were found to have abnormal personality traits, and escitalopram was efficacious and had a good safety profile in the treatment of geriatric depression.
引用
收藏
页码:1946 / 1953
页数:8
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