Prevention by rebamipide of acute reflux esophagitis in rats

被引：19

作者：

Katada, K ^{[1
]}

Yoshida, N ^{[1
]}

Isozaki, Y ^{[1
]}

Tomatsuri, N ^{[1
]}

Ichikawa, H ^{[1
]}

Naito, Y ^{[1
]}

Okanoue, T ^{[1
]}

Yoshikawa, T ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2005年 / 50卷 / Suppl 1期

关键词：

reflux esophagitis; rebamipide; neutrophils; lipid peroxidation; TNF-alpha; CINC-1;

D O I：

10.1007/s10620-005-2813-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Proinflammatory factors, including neutrophil-derived oxygen free radicals and inflammatory cytokines, have recently been implicated in the pathogenesis of reflux esophagitis. Rebamipide has been widely used as an anti-ulcer agent. The aim of the present study was to assess the protective effect of rebamipide against acute reflux esophagitis in rats. Esophagitis was induced in rats by ligation at the limiting ridge and the lower portion of the duodenum. Vehicle or rebamipide were given as a single dose intraduodenally. Lesion index (LI), thiobarbituric acid-reactive substances (TBA-RS), myeloperoxidase (MPO) activity, mRNA and protein of tumor necrosis factor (TNF)-alpha and cytokine-induced neutrophil chemoattractant (CINC)-1 in the esophageal mucosa were markedly increased; pretreatment with rebamipide, however, significantly reduced both macroscopic and microscopic injuries and increases in inflammatory mediators. The results of this study indicate that rebamipide protects against the occurrence of esophagitis and has highly promising potential as a new therapeutic agent for reflux esophagitis.

引用

页码：S97 / S103

页数：7

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