Imbalance of programmed CD4+ and CD8+ lymphocyte death in patients with chronic viral infections

被引：0

作者：

Chechina, O. E. ^{[1
]}

Zhukova, O. B.

Ryazantseva, N. V.

Novitsky, V. V.

Tkachenko, S. B.

机构：

[1] Siberian State Med Univ, Tomsk, Russia

来源：

GEMATOLOGIYA I TRANSFUZIOLOGIYA | 2008年 / 53卷 / 02期

关键词：

lymphocytes; chronic viral infection; apoptosis;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 76 patients with hepatitis C and tick-borne encephalitis revealed deficiency of T-cellular immunity. This defect is caused by disorders in lymphocyte apoptosis. Annexin test showed reduced apoptosis in patients with chronic viral hepatitis C and increased numbers of apoptotic lymphocytes in patients with tick-borne encephalitis. Differentiated evaluation of CD4(+) and CD8(+) lymphocyte apoptosis showed that long persistence of hepatitis C virus leads to increase of T-helper sensitivity to apoptosis induction. In patients with tick-borne encephalitis suppression of CD4(+) cell apoptosis realization was observed. Inhibition of CD8(+) lymphocyte apoptosis was detected also in patients with tick-borne encephalitis.

引用

页码：38 / 41

页数：4

共 20 条

[1] ARENDS MJ, 1991, INT REV EXP PATHOL, V32, P223
[2] Mechanisms of viral clearance and persistence
Borrow, P
[J]. JOURNAL OF VIRAL HEPATITIS, 1997, 4 : 16 - 24
[3] LYMPHOCYTE-T RESPONSE TO HEPATITIS-C VIRUS IN DIFFERENT CLINICAL COURSES OF INFECTION
BOTARELLI, P
BRUNETTO, MR
MINUTELLO, MA
CALVO, P
UNUTMAZ, D
WEINER, AJ
CHOO, QL
SHUSTER, JR
KUO, G
BONINO, F
HOUGHTON, M
ABRIGNANI, S
[J]. GASTROENTEROLOGY, 1993, 104 (02) : 580 - 587
[4] CHECHINA OY, 2005, BYUL SIB MED, P78
[5] PATHOLOGY OF HEPATITIS-C VIRUS-INFECTION
DHILLON, AP
DUSHEIKO, GM
[J]. HISTOPATHOLOGY, 1995, 26 (04) : 297 - 309
[6] GRIGORYEVA TY, 2002, IMMUNOLOGIYA, P200
[7] A time to kill: viral manipulation of the cell death program
Hay, S
Kannourakis, G
[J]. JOURNAL OF GENERAL VIROLOGY, 2002, 83 : 1547 - 1564
[8] IVASHKIN VT, 1995, ROS MED ZH, V1, P26
[9] APOPTOSIS - BASIC BIOLOGICAL PHENOMENON WITH WIDE-RANGING IMPLICATIONS IN TISSUE KINETICS
KERR, JFR
WYLLIE, AH
CURRIE, AR
[J]. BRITISH JOURNAL OF CANCER, 1972, 26 (04) : 239 - +
[10] KHAITOV RM, 2000, IMMUNOLOGIYA, P61

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