Intrapatient escape in the A*0201-restricted epitope SLYNTVATL drives evolution of human immunodeticiency virus type 1 at the population level

被引：12

作者：

Edwards, CTT

Pfafferott, KJ

Goulder, PJR

Phillips, RE

Holmes, EC

机构：

[1] Univ Oxford, Nuffield Dept Clin Med, Peter Medawar Bldg Pathogen Res, Oxford OX1 3SY, England

[2] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

JOURNAL OF VIROLOGY | 2005年 / 79卷 / 14期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.79.14.9363-9366.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The hypothesis that the intrapatient emergence of cytotoxic T-lymphocyte escape variants contributes to the evolution of human immunodeficiency virus type I at the population (interpatient) level was tested using the HLA-A*0201-restricted gag p17 epitope SLYNTVATL. Using a simple experimental design, we investigated the evolutionary processes operating within this epitope among patients while compensating for the confounding influence of intrapatient natural selection. Using this approach, we revealed a pattern of A*0201-driven escape within patients, followed by the sustained transmission of these escape variants among patients irrespective of their HLA type.

引用

页码：9363 / 9366

页数：4

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