Synthesis and Anti-Hepatitis B Virus Activities of Galactopyranosyl Derivatives of Matijin-Su

被引：2

作者：

Xu, Guangcan ^{[1
,2
,4
]}

Liu, Qingchuan ^{[3
]}

Yuan, Jie ^{[1
,2
,5
]}

Hu, Zhanxing ^{[1
,2
]}

Ma, Fanggang ^{[1
,2
,4
]}

Liang, Guangyi ^{[1
,2
,4
]}

Xu, Bixue ^{[1
,2
]}

机构：

[1] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China

[2] Chinese Acad Sci, Guiyang 550002, Peoples R China

[3] 302 Hosp PLA, Beijing 100039, Peoples R China

[4] Guiyang Coll Tradit Chinese Med, Guiyang 550002, Peoples R China

[5] Guizhou Univ, Coll Pharm, Guiyang 550002, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 36卷 / 07期

基金：

中国国家自然科学基金;

关键词：

hepatic targeting; derivatives of Matijin-Su; glacatose; anti-hepatitis B virus activity; BIOLOGICAL EVALUATION;

D O I：

10.6023/cjoc201512051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

To improve the concentration in liver lesion tissue and increase the anti-hepatitis B virus (HBV) activities of Matijin-Su (MTS) derivatives, five hepatic targeting galactopyranosyl derivatives of MTS were synthesized by indirect connecting the liver targeting galactose ligands to MTS using ethanolamin as a linker and their structures were confirmed by H-1 NMR, (CNMR)-C-13, H-1-H-1 COSY, HMQC and ESI-MS. The anti-HBV activities of those compounds were evaluated in HepG2 2.2.15 cells. The screening results showed that all target compounds had inhibitory effect on HBV DNA replication in HepG2 2.2.15 cells in a dose-response manner.

引用

页码：1617 / 1625

页数：9

共 22 条

[1] LONG-ACTING DIHYDROPYRIDINE CALCIUM-ANTAGONISTS .9. STRUCTURE-ACTIVITY-RELATIONSHIPS AROUND AMLODIPINE [J].

ALKER, D ;

ARROWSMITH, JE ;

CAMPBELL, SF ;

CROSS, PE .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1991, 26 (09) :907-913

[2] Preparation and Biological Evaluation of a Glycosylated Fusion Interferon Directed to Hepatic Receptors [J].

Cai, Gangming ;

Jiang, Mengjun ;

Zhang, Bo ;

Zhou, Yaoyuan ;

Zhang, Lianfen ;

Lei, Jianyong ;

Gu, Xiaobo ;

Cao, Guoxian ;

Jin, Jian ;

Zhang, Rongjun .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2009, 32 (03) :440-443

[3]

Cai M. S., 2006, CARBOHYDRATE CHEM FU, P370

[4] Synthesis of N-Oxyamide-Linked Neoglycolipids [J].

Chen, Na ;

Xie, Juan .

JOURNAL OF ORGANIC CHEMISTRY, 2014, 79 (21) :10716-10721

[5]

Chu Y., 2014, THESIS

[6] Synthesis and Anti-hepatitis B Virus Activities of Nitric Oxide-Releasing Derivatives of Matijin-Su [J].

Liang, Guangping ;

Cao, Peixue ;

Yang, Xiuxie ;

Huang, Zhengming ;

Liu, Qingchuan ;

Liang, Guangyi ;

Xu, Bixue .

CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2014, 34 (05) :973-979

[7] Novel synthesis of substituted pyrrolidines and piperidines via radical addition - ionic cyclization reaction of oxime ethers [J].

Miyata, Okiko ;

Takahashi, Shinya ;

Tamura, Akira ;

Ueda, Masafumi ;

Naito, Takeaki .

TETRAHEDRON, 2008, 64 (07) :1270-1284

[8]

MORELL AG, 1971, J BIOL CHEM, V246, P1461

[9] Reverse-CD mimics with flexible linkages offer adaptable cavity sizes for guest encapsulation [J].

Pathigoolla, Atchutarao ;

Sureshan, Kana M. .

CHEMICAL COMMUNICATIONS, 2014, 50 (03) :317-319

[10]

Pierre V.-D., 2010, ADV EXP MED BIOL, V659, P175

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