Substrate-Controlled, Phosphine-Catalyzed Domino Reactions of Activated Conjugated Dienes: Highly Diastereoselective Synthesis of Bicyclic Skeletons

被引：60

作者：

Ma, Jianze ^{[1
,2
]}

Xie, Peizhong ^{[1
,2
]}

Hu, Chongchong ^{[1
,2
]}

Huang, You ^{[1
,2
]}

Chen, Ruyu ^{[1
,2
]}

机构：

[1] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 27期

基金：

中国国家自然科学基金;

关键词：

domino reactions; Michael reaction; organocatalysis; phosphine; Rauhut-Currier reaction; RAUHUT-CURRIER REACTION; ANTI-MICHAEL ADDITION; N-THIOPHOSPHINYL IMINES; STEREOSELECTIVE-SYNTHESIS; REGIOSPECIFIC APPROACH; CYCLOISOMERIZATION; TRANSFORMATIONS; SUBSTITUTION; DERIVATIVES; BIS(ENONES);

D O I：

10.1002/chem.201100881

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A single catalyst, multiple dominos: The intermolecular Rauhut-Currier (RC) reaction of activated conjugated dienes enables unprecedented substrate-controlled phosphine-mediated domino reactions by two catalytic models, which generate bicyclic skeletons with high diastereoselectivities (see scheme). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7418 / 7422

页数：5

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