Combined Therapy of Gastrointestinal Stromal Tumors

被引：21

作者：

Rutkowski, Piotr ^{[1
]}

Hompes, Daphne ^{[2
]}

机构：

[1] Maria Sklodowska Curie Mem Canc Ctr, Inst Oncol, Dept Soft Tissue Bone Sarcoma & Melanoma, Roentgena 5, PL-02781 Warsaw, Poland

[2] Univ Hosp Gasthuisberg Leuven, Dept Surg Oncol, Herestr 49, B-3000 Leuven, Belgium

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2016年 / 25卷 / 04期

关键词：

Gastrointestinal stromal tumor; Neoadjuvant therapy; Adjuvant therapy; Imatinib; Surgery; TYROSINE-KINASE INHIBITOR; PHASE-II TRIAL; TERM-FOLLOW-UP; NEOADJUVANT/ADJUVANT IMATINIB MESYLATE; CLINICAL-PRACTICE GUIDELINES; ADJUVANT IMATINIB; SURGICAL RESECTION; HIGH-RISK; PROGNOSTIC-FACTORS; PDGFRA MUTATIONS;

D O I：

10.1016/j.soc.2016.05.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radical surgery is the mainstay of therapy for primary resectable, localized gastrointestinal stromal tumors (GIST). Nevertheless, approximately 40% to 50% of patients with potentially curative resections develop recurrent or metastatic disease. The introduction of imatinib mesylate has revolutionized the therapy of advanced (inoperable and/or metastatic) GIST and has become the standard of care in treatment of patients with advanced GIST. This article discusses the proper selection of candidates for adjuvant and neoadjuvant treatment in locally advanced GIST, exploring the available evidence behind the combination of preoperative imatinib and surgery.

引用

页码：735 / +

页数：27

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