Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?

被引：16

作者：

Conerly, Melissa L. ^{[1
,2
]}

MacQuarrie, Kyle L. ^{[1
,3
]}

Fong, Abraham P. ^{[1
]}

Yao, Zizhen ^{[4
]}

Tapscott, Stephen J. ^{[1
,5
,6
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA

[2] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

[3] Univ Washington, Mol & Cellular Biol Program, Seattle, WA 98105 USA

[4] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA

[5] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[6] Univ Washington, Dept Neurol, Seattle, WA 98105 USA

来源：

GENES & DEVELOPMENT | 2011年 / 25卷 / 10期

关键词：

Polycomb; Ezh2; satellite cells; muscle growth; muscle regeneration; HISTONE METHYLTRANSFERASE ACTIVITY; SKELETAL-MUSCLE DIFFERENTIATION; H3; LYSINE-27; METHYLATION; SATELLITE CELLS; GENE-EXPRESSION; STEM-CELLS; PROGENITOR CELLS; NONCODING RNAS; GROUP PROTEINS; SELF-RENEWAL;

D O I：

10.1101/gad.2054311

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chromatin-modifying enzymes are known to be critical components for the correct differentiation of embryonic stem cells into specific lineages, such as neurons. Recently, the role of Polycomb group proteins has been studied in the specification and differentiation of muscle stem cells. In this perspective, we review a recent study by Juan and colleagues (pp. 789-794) in Genes & Development of the role of the polycomb group protein Ezh2 in muscle stem cells, and discuss the implications for general lineage restriction.

引用

页码：997 / 1003

页数：7

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