Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy

被引：34

作者：

Fehr, C ^{[1
]}

Schleicher, A ^{[1
]}

Szegedi, A ^{[1
]}

Anghelescu, I ^{[1
]}

Klawe, C ^{[1
]}

Hiemke, C ^{[1
]}

Dahmen, N ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Psychiat, D-6500 Mainz, Germany

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2001年 / 25卷 / 05期

关键词：

alcoholism genetics; anxiety disorders; 5-HTR2A; narcolepsy genetics; psychiatric genetics; serotonin; tryptophan hydroxylase polymorphism;

D O I：

10.1016/S0278-5846(01)00171-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Alterations in the serotonergic neurotransmission have been frequently described for patients suffering from alcoholism, anxiety disorders and narcolepsy. 2. The authors tested for association of the 5-HT2A receptor polymorphism (T102C) and the intron 7 tryptophan hydroxylase (TPH) polymorphism (A218C) among 176 alcohol dependent patients, 35 patients with panic disorder, 50 patients with generalized anxiety disorder, 55 patients with narcolepsy and 87 healthy controls. 3. Allele and genotype frequencies of the 5-HT2A receptor polymorphism (T102C), the intron 7 TPH polymorphism (A218C) were almost similar between the patients suffering from alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy. 4. There was no association between the 5-HT2A receptor polymorphism (T102C), the intron7 TPH (A218C) polymorphisms and alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy in our subsets of German patients.

引用

页码：965 / 982

页数：18

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