The Role of Iron in Cancer Progression

被引：100

作者：

Guo, Qianqian ^{[1
]}

Li, Liwen ^{[3
]}

Hou, Shanshan ^{[4
]}

Yuan, Ziqiao ^{[5
]}

Li, Chenhui ^{[3
]}

Zhang, Wenzhou ^{[1
]}

Zheng, Lufeng ^{[3
]}

Li, Xiaoman ^{[2
]}

机构：

[1] Zhengzhou Univ, Henan Canc Hosp, Affiliated Canc Hosp, Dept Pharm, Zhengzhou, Peoples R China

[2] Nanjing Univ Chinese Med, Sch Pharm, Jiangsu Key Lab Pharmacol & Safety Evaluat Chines, Nanjing, Peoples R China

[3] China Pharmaceut Univ, Sch Life Sci & Technol, Sch Basic Med & Clin Pharm, Jiangsu Key Lab Carcinogenesis & Intervent, Nanjing, Peoples R China

[4] Zhejiang Pharmaceut Coll, Dept Pharm, Ningbo, Peoples R China

[5] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

iron; cancer; ferroptosis; ferritinophagy; prognostic; therapy; NEGATIVE BREAST-CANCER; PREDICTS POOR-PROGNOSIS; SERUM FERRITIN LEVEL; PHASE-II TRIAL; LUNG-CANCER; CELL-DEATH; COLORECTAL-CANCER; GALLIUM NITRATE; TUMOR-GROWTH; THERAPEUTIC TARGET;

D O I：

10.3389/fonc.2021.778492

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Iron is an essential trace element for the human body, and its deficiency or excess can induce a variety of biological processes. Plenty of evidences have shown that iron metabolism is closely related to the occurrence and development of tumors. In addition, iron plays an important role in cell death, which is very important for the development of potential strategies for tumor treatment. Here, we reviewed the latest research about iron metabolism disorders in various types of tumors, the functions and properties of iron in ferroptosis and ferritinophagy, and new opportunities for iron-based on treatment methods for tumors, providing more information regarding the prevention and treatment of tumors.

引用

页数：18

共 236 条

[11] Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells [J].

Asano, Takeshi ;

Komatsu, Masaaki ;

Yamaguchi-Iwai, Yuko ;

Ishikawa, Fuyuki ;

Mizushima, Noboru ;

Iwai, Kazuhiro .

MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (10) :2040-2052

[12] miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma [J].

Babu, Kamesh R. ;

Muckenthaler, Martina U. .

SCIENTIFIC REPORTS, 2019, 9 (1)

[13] miR-20a regulates expression of the iron exporter ferroportin in lung cancer [J].

Babu, Kamesh R. ;

Muckenthaler, Martina U. .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2016, 94 (03) :347-359

[14] Cysteine depletion induces pancreatic tumor ferroptosis in mice [J].

Badgley, Michael A. ;

Kremer, Daniel M. ;

Maurer, H. Carlo ;

DelGiorno, Kathleen E. ;

Lee, Ho-Joon ;

Purohit, Vinee ;

Sagalovskiy, Irina R. ;

Ma, Alice ;

Kapilian, Jonathan ;

Firl, Christina E. M. ;

Decker, Amanda R. ;

Sastra, Steve A. ;

Palermo, Carmine F. ;

Andrade, Leonardo R. ;

Sajjakulnukit, Peter ;

Zhang, Li ;

Tolstyka, Zachary P. ;

Hirschhorn, Tal ;

Lamb, Candice ;

Liu, Tong ;

Gu, Wei ;

Seeley, E. Scott ;

Stone, Everett ;

Georgiou, George ;

Manor, Uri ;

Iuga, Alina ;

Wahl, Geoffrey M. ;

Stockwell, Brent R. ;

Lyssiotis, Costas A. ;

Olive, Kenneth P. .

SCIENCE, 2020, 368 (6486) :85-+

[15] Lipid storage and lipophagy regulates ferroptosis [J].

Bai, Yuansong ;

Meng, Lingjun ;

Han, Leng ;

Jia, Yuanyuan ;

Zhao, Yanan ;

Gao, Huan ;

Kang, Rui ;

Wang, Xiaofeng ;

Tang, Daolin ;

Dai, Enyong .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 508 (04) :997-1003

[16] Estrogen-dependent disruption of intracellular iron metabolism augments the cytotoxic effects of doxorubicin in select breast and ovarian cancer cells [J].

Bajbouj, Khuloud ;

Shafarin, Jasmin ;

Hamad, Mawieh .

CANCER MANAGEMENT AND RESEARCH, 2019, 11 :4655-4668

[17] MEF2C silencing downregulates NF2 and E-cadherin and enhances Erastin-induced ferroptosis in meningioma [J].

Bao, Zhongyuan ;

Hua, Lingyang ;

Ye, TYangfan ;

Wang, Daijun ;

Li, Chong ;

Xie, Qing ;

Wakimoto, Hiroaki ;

Gong, Ye ;

Ji, Jing .

NEURO-ONCOLOGY, 2021, 23 (12) :2014-2027

[18] Iron addiction: a novel therapeutic target in ovarian cancer [J].

Basuli, D. ;

Tesfay, L. ;

Deng, Z. ;

Paul, B. ;

Yamamoto, Y. ;

Ning, G. ;

Xian, W. ;

McKeon, F. ;

Lynch, M. ;

Crum, C. P. ;

Hegde, P. ;

Brewer, M. ;

Wang, X. ;

Miller, L. D. ;

Dyment, N. ;

Torti, F. M. ;

Torti, S. V. .

ONCOGENE, 2017, 36 (29) :4089-4099

[19] Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 [J].

Beatty, Alexander ;

Singh, Tanu ;

Tyurina, Yulia Y. ;

Tyurin, Vladimir A. ;

Samovich, Svetlana ;

Nicolas, Emmanuelle ;

Maslar, Kristen ;

Zhou, Yan ;

Cai, Kathy Q. ;

Tan, Yinfei ;

Doll, Sebastian ;

Conrad, Marcus ;

Subramanian, Aravind ;

Kagan, Valerian E. ;

Rennefahrt, Ulrike ;

Peterson, Jeffrey R. ;

Bayir, Hulya .

NATURE COMMUNICATIONS, 2021, 12 (01)

[20] NCOA4 Deficiency Impairs Systemic Iron Homeostasis [J].

Bellelli, Roberto ;

Federico, Giorgia ;

Matte', Alessandro ;

Colecchia, David ;

Iolascon, Achille ;

Chiariello, Mario ;

Santoro, Massimo ;

De Franceschi, Lucia ;

Carlomagno, Francesca .

CELL REPORTS, 2016, 14 (03) :411-421

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