The Role of Iron in Cancer Progression

被引：100
作者：
Guo, Qianqian [1 ]
Li, Liwen [3 ]
Hou, Shanshan [4 ]
Yuan, Ziqiao [5 ]
Li, Chenhui [3 ]
Zhang, Wenzhou [1 ]
Zheng, Lufeng [3 ]
Li, Xiaoman [2 ]
机构：
[1] Zhengzhou Univ, Henan Canc Hosp, Affiliated Canc Hosp, Dept Pharm, Zhengzhou, Peoples R China
[2] Nanjing Univ Chinese Med, Sch Pharm, Jiangsu Key Lab Pharmacol & Safety Evaluat Chines, Nanjing, Peoples R China
[3] China Pharmaceut Univ, Sch Life Sci & Technol, Sch Basic Med & Clin Pharm, Jiangsu Key Lab Carcinogenesis & Intervent, Nanjing, Peoples R China
[4] Zhejiang Pharmaceut Coll, Dept Pharm, Ningbo, Peoples R China
[5] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
基金：
中国国家自然科学基金;
关键词：
iron; cancer; ferroptosis; ferritinophagy; prognostic; therapy; NEGATIVE BREAST-CANCER; PREDICTS POOR-PROGNOSIS; SERUM FERRITIN LEVEL; PHASE-II TRIAL; LUNG-CANCER; CELL-DEATH; COLORECTAL-CANCER; GALLIUM NITRATE; TUMOR-GROWTH; THERAPEUTIC TARGET;
D O I：
10.3389/fonc.2021.778492
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Iron is an essential trace element for the human body, and its deficiency or excess can induce a variety of biological processes. Plenty of evidences have shown that iron metabolism is closely related to the occurrence and development of tumors. In addition, iron plays an important role in cell death, which is very important for the development of potential strategies for tumor treatment. Here, we reviewed the latest research about iron metabolism disorders in various types of tumors, the functions and properties of iron in ferroptosis and ferritinophagy, and new opportunities for iron-based on treatment methods for tumors, providing more information regarding the prevention and treatment of tumors.
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页数：18
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