The sarcoglycan complex in limb-girdle muscular dystrophy

被引：117
作者：
Lim, LE
Campbell, KP [1 ]
机构：
[1] Univ Iowa, Coll Med, Howard Hughes Med Inst, Dept Physiol & Biophys, Iowa City, IA 52242 USA
[2] Univ Iowa, Coll Med, Dept Neurol, Iowa City, IA 52242 USA
来源：
CURRENT OPINION IN NEUROLOGY | 1998年 / 11卷 / 05期
关键词：
D O I：
10.1097/00019052-199810000-00006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The involvement of the sarcoglycan complex in the pathogenesis of muscular dystrophy is becoming increasingly clear. Sarcoglycan gene mutations lead to four forms of autosomal recessive limb-girdle muscular dystrophy. Recent progress has been made with the identification of novel mutations and their correlations with disease. Through this research, a better understanding the molecular pathogenesis of limb-girdle muscular dystrophy has been gained. Finally, animal models are now being used to study viral-mediated gene transfer for the future treatment of this disease. Curr Opin Neurol 11:443-452. (C) 1998 Lippincott Williams & Wilkins.
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页码：443 / 452
页数：10
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