Activation of the left amygdala to a cognitive representation of fear

被引:691
作者
Phelps, EA
O'Connor, KJ
Gatenby, JC
Gore, JC
Grillon, C
Davis, M
机构
[1] NYU, Dept Psychol, New York, NY 10003 USA
[2] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA
[3] Yale Univ, Sch Med, Dept Radiol, New Haven, CT 06520 USA
[4] NIMH, Bethesda, MD 20892 USA
[5] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
关键词
D O I
10.1038/86110
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We examined the neural substrates involved when subjects encountered an event linked verbally, but not experientially, to an aversive outcome. This instructed fear task models a primary way humans learn about the emotional nature of events. Subjects were told that one stimulus (threat) represents an aversive event (a shock may be given), whereas another (safe) represents safety (no shock will be given). Using functional magnetic resonance imaging (fMRI), activation of the left amygdala was observed in response to threat versus safe conditions, which correlated with the expression of the fear response as measured by skin conductance. Additional activation observed in the insular cortex is proposed to be involved in conveying a cortical representation of fear to the amygdala. These results suggest that the neural substrates that support conditioned fear across species have a similar but somewhat different role in more abstract representations of fear in humans.
引用
收藏
页码:437 / 441
页数:5
相关论文
共 30 条
[1]   Startle reflex and emotion modulation impairment after a right amygdala lesion [J].
Angrilli, A ;
Mauri, A ;
Palomba, D ;
Flor, H ;
Birbaumer, N ;
Sartori, G ;
diPaola, F .
BRAIN, 1996, 119 :1991-2000
[2]  
[Anonymous], 1996, The Emotional Brain
[3]  
[Anonymous], NEUROPSYCHOLOGY MEMO
[4]   DOUBLE DISSOCIATION OF CONDITIONING AND DECLARATIVE KNOWLEDGE RELATIVE TO THE AMYGDALA AND HIPPOCAMPUS IN HUMANS [J].
BECHARA, A ;
TRANEL, D ;
DAMASIO, H ;
ADOLPHS, R ;
ROCKLAND, C ;
DAMASIO, AR .
SCIENCE, 1995, 269 (5227) :1115-1118
[5]   Response and habituation of the human amygdala during visual processing of facial expression [J].
Breiter, HC ;
Etcoff, NL ;
Whalen, PJ ;
Kennedy, WA ;
Rauch, SL ;
Buckner, RL ;
Strauss, MM ;
Hyman, SE ;
Rosen, BR .
NEURON, 1996, 17 (05) :875-887
[6]   Brain systems mediating aversive conditioning:: an event-related fMRI study [J].
Büchel, C ;
Morris, J ;
Dolan, RJ ;
Friston, KJ .
NEURON, 1998, 20 (05) :947-957
[7]   Statistical methods of estimation and inference for functional MR image analysis [J].
Bullmore, E ;
Brammer, M ;
Williams, SCR ;
Rabehesketh, S ;
Janot, N ;
David, A ;
Mellers, J ;
Howard, R ;
Sham, P .
MAGNETIC RESONANCE IN MEDICINE, 1996, 35 (02) :261-277
[8]  
Bush G, 1998, HUM BRAIN MAPP, V6, P270, DOI 10.1002/(SICI)1097-0193(1998)6:4<270::AID-HBM6>3.3.CO
[9]  
2-H
[10]  
Collins DR, 1999, J NEUROSCI, V19, P836