Architectural proteins for the formation and maintenance of the 3D genome

被引：10
作者：
Li, Mengfan [1 ,2 ]
Gan, Jingbo [1 ,2 ]
Sun, Yuao [1 ,2 ,3 ,4 ]
Xu, Zihan [1 ,2 ]
Yang, Junsheng [1 ,2 ,3 ,4 ]
Sun, Yujie [3 ,4 ]
Li, Cheng [5 ]
机构：
[1] Peking Univ, Peking Tsinghua Ctr Life Sci, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
[2] Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China
[3] Peking Univ, Sch Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China
[4] Peking Univ, Biomed Pioneering Innovat Ctr BIOPIC, Beijing 100871, Peoples R China
[5] Peking Univ, Sch Life Sci, Ctr Stat Sci, Ctr Bioinformat, Beijing 100871, Peoples R China
来源：
SCIENCE CHINA-LIFE SCIENCES | 2020年 / 63卷 / 06期
基金：
中国国家自然科学基金;
关键词：
3D genome; architectural protein; Hi-C; DNA-BINDING PROTEIN; HI-C REVEALS; PHASE-SEPARATION; CHROMATIN-STRUCTURE; NUCLEAR-MATRIX; 3-DIMENSIONAL GENOME; SISTER CHROMATIDS; CTCF SITES; HEAT-SHOCK; ORGANIZATION;
D O I：
10.1007/s11427-019-1613-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Eukaryotic genomes are densely packaged into hierarchical three-dimensional (3D) structures that contain information about gene regulation and many other biological processes. With the development of imaging and sequencing-based technologies, 3D genome studies have revealed that the high-order chromatin structure is composed of hierarchical levels, including chromosome territories, A/B compartments, topologically associated domains, and chromatin loops. However, how this chromatin architecture is formed and maintained is not completely clear. In this review, we introduce experimental methods to investigate the 3D genome, review major architectural proteins that regulate 3D chromatin organization in mammalian cells, such as CTCF (CCCTC-binding factor), cohesin, lamins, and transcription factors, and discuss relevant mechanisms such as phase separation.
引用
收藏
页码：795 / 810
页数：16
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