Tetrocarcins N and O, glycosidic spirotetronates from a marine-derived Micromonospora sp identified by PCR-based screening

被引：19

作者：

Tan, Yi ^{[1
,2
]}

Hu, Yuanyuan ^{[1
,2
]}

Wang, Qiang ^{[1
,2
]}

Zhou, Hongxia ^{[1
,2
]}

Wang, Yiguang ^{[1
,2
]}

Gan, Maoluo ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 94期

基金：

中国国家自然科学基金;

关键词：

ANTI-TUMOR ANTIBIOTICS; FERMENTATION; APOPTOSIS;

D O I：

10.1039/c6ra17026a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new glycosidic spirotetronate antibiotics, tetrocarcins N (1) and O (2), were isolated and identified from the marine-derived Micromonospora sp. 5-297 using a PCR-based genetic screening method targeting the dTDP-glucose-4,6-dehydratase gene. Their structures were determined by extensive IR, NMR, and MS spectroscopic analyses. Tetrocarcin O (2) is a derivative of 1 that lacks the terminal L-amicetose moiety at C-9. Compound 1 and 2 exhibited antibacterial activity against Bacillus subtilis with MIC values of 2 and 64 mu g mL(-1), respectivly. It seems that the sugar moieties at C-9 and the formyl group at C-32 play important roles in the antibacterial activity of the tetrocarcins.

引用

页码：91773 / 91778

页数：6

共 21 条

[1] Tetrocarcin-A-induced ER stress mediates apoptosis in B-CLL cells via a Bcl-2-independent pathway [J].