Combination of an antiviral drug and immunomodulation against hepadnaviral infection in the woodchuck model

被引：34

作者：

Lu, Mengji ^{[1
]}

Yao, Xin ^{[2
]}

Xu, Yang ^{[1
]}

Lorenz, Heike ^{[3
]}

Dahmen, Uta ^{[4
]}

Chi, Haidong ^{[4
]}

Dirsch, Olaf ^{[5
]}

Kemper, Thekla ^{[1
]}

He, Lifang ^{[2
]}

Glebe, Dieter ^{[3
]}

Gerlich, Wolfram H. ^{[3
]}

Wen, Yumei ^{[2
]}

Roggendorf, Michael ^{[1
]}

机构：

[1] Univ Klinikum Essen, Inst Virol, D-45122 Essen, Germany

[2] Fudan Univ, Med Ctr, Dept Mol Virol, Shanghai 200433, Peoples R China

[3] Univ Giessen, Inst Med Virol, Giessen, Germany

[4] Univ Klinikum Essen, Klin Allgemein Viszeral & Transplantat Chirurg, Essen, Germany

[5] Univ Klin Koln, Inst Pathol, Cologne, Germany

来源：

JOURNAL OF VIROLOGY | 2008年 / 82卷 / 05期

关键词：

D O I：

10.1128/JVI.01613-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The essential role of multispecific immune responses for the control of hepatitis B virus (HBV) infection implies the need of multimodal therapeutic strategies for chronic HBV infection, including antiviral chemotherapy and immunomodulation. This hypothesis was tested in the woodchuck model by a combination of lamivudine pretreatment and subsequent immunizations of woodchucks chronically infected with woodchuck hepatitis virus. The immunizations were performed with DNA vaccines or antigen-antibody immune complexes (IC)/DNA vaccines. Immunizations with IC/DNA vaccines led to an anti-woodchuck hepatitis virus surface antibody response and significant reductions of viral load and antigenemia, suggesting that such a strategy may be effective against chronic HBV infection.

引用

页码：2598 / 2603

页数：6

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