EANO guideline on the diagnosis and treatment of vestibular schwannoma

被引：271

作者：

Goldbrunner, Roland ^{[1
]}

Weller, Michael ^{[2
,3
]}

Regis, Jean ^{[4
]}

Lund-Johansen, Morten ^{[5
,6
]}

Stavrinou, Pantelis ^{[1
]}

Reuss, David ^{[7
]}

Evans, D. Gareth ^{[8
,9
]}

Lefranc, Florence ^{[10
]}

Sallabanda, Kita ^{[11
,12
]}

Falini, Andrea ^{[13
,14
]}

Axon, Patrick ^{[15
]}

Sterkers, Olivier ^{[16
]}

Fariselli, Laura ^{[17
]}

Wick, Wolfgang ^{[18
,19
]}

Tonn, Joerg-Christian ^{[20
,21
]}

机构：

[1] Univ Cologne, Dept Gen Neurosurg, Ctr Neurosug, Kerpener Str 62, D-50937 Cologne, Germany

[2] Univ Hosp, Dept Neurol, Zurich, Switzerland

[3] Univ Zurich, Zurich, Switzerland

[4] Timone Univ Hosp, Dept Funct & Stereotact Neurosurg & Radiosurg, Marseille, France

[5] Univ Bergen, Bergen Univ Hosp, Dept Neurosurg, Bergen, Norway

[6] Univ Bergen, Fac Med & Dent, Dept Clin Med, Bergen, Norway

[7] Univ Hosp Heidelberg, Dept Neuropathol, Heidelberg, Germany

[8] Manchester Univ Hosp NHS Fdn Trust, Manchester Ctr Genom Med, Manchester, Lancs, England

[9] Manchester Univ Hosp NHS Fdn Trust, NW Lab Genet Hub, Manchester, Lancs, England

[10] Free Univ Brussels, Erasmus Hosp, Dept Neurosurg, Brussels, Belgium

[11] Univ Complutense Madrid, Univ Hosp San Carlos, Dept Neurosurg, Madrid, Spain

[12] Univ Hosp San Carlos, CyberKnife Ctr, Genesiscare Madrid, Madrid, Spain

[13] IRCCS San Raffaele Sci Inst, Dept Neuroradiol, Milan, Italy

[14] Univ Vita Salute San Raffaele, Milan, Italy

[15] Cambridge Univ Hosp NHS Fdn Trust, Cambridge Skull Base Unit, Cambridge, England

[16] Pitie Salpetriere Grp Hosp, AP HP, Unit Otol Auditory implants & Skull Base Surg, Dept Otolaryngol, Paris, France

[17] Neurol Inst Carlo Best, Unit Radiotherapy, Milan, Italy

[18] Univ Hosp Heidelberg, Neurol Clin, Heidelberg, Germany

[19] Univ Hosp Heidelberg, Natl Ctr Tumor Dis, Heidelberg, Germany

[20] Univ Munich, Ludwig Maximilians Univ, Dept Neurosurg, Munich, Germany

[21] Univ Munich, DKTK Partner Site, Munich, Germany

来源：

NEURO-ONCOLOGY | 2020年 / 22卷 / 01期

关键词：

diagnosis; radiotherapy; surgery; treatment; vestibular schwannoma; GAMMA-KNIFE RADIOSURGERY; QUALITY-OF-LIFE; CENTRAL-NERVOUS-SYSTEM; METHYLATION-BASED CLASSIFICATION; ACOUSTIC NEUROMA SURGERY; CRANIAL FOSSA APPROACH; TO-END HYPOGLOSSAL; FACIAL-NERVE; STEREOTACTIC RADIOSURGERY; NEUROFIBROMATOSIS TYPE-2;

D O I：

10.1093/neuonc/noz153

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The level of evidence to provide treatment recommendations for vestibular schwannoma is low compared with other intracranial neoplasms. Therefore, the vestibular schwannoma task force of the European Association of Neuro-Oncology assessed the data available in the literature and composed a set of recommendations for health care professionals.The radiological diagnosis of vestibular schwannoma is made by magnetic resonance imaging. Histological verification of the diagnosis is not always required. Current treatment options include observation, surgical resection, fractionated radiotherapy, and radiosurgery. The choice of treatment depends on clinical presentation, tumor size, and expertise of the treating center. In small tumors, observation has to be weighed against radiosurgery, in large tumors surgical decompression is mandatory, potentially followed byfractionated radiotherapy or radiosurgery. Except for bevacizumab in neurofibromatosis type 2, there is no role for pharmacotherapy.

引用

页码：31 / 45

页数：15

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