Diphasic Worsening of Freezing of Gait in Parkinson's Disease

被引：9

作者：

Parra, Sahyli ^{[1
]}

McKay, J. Lucas ^{[2
,3
]}

Factor, Stewart A. ^{[1
]}

机构：

[1] Emory Univ, Dept Neurol, Jean & Paul Amos PD & Movement Disorders Program, Atlanta, GA 30322 USA

[2] Georgia Tech, Wallace H Coulter Dept Biomed Engn, Atlanta, GA USA

[3] Emory Univ, Atlanta, GA 30322 USA

来源：

MOVEMENT DISORDERS CLINICAL PRACTICE | 2020年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Parkinson's disease; freezing of gait; levodopa; diphasic;

D O I：

10.1002/mdc3.12918

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background The relationship between freezing of gait (FOG) and levodopa response is complex. Some patients respond, some have no response and in some patients levodopa causes FOG. We present 2 cases demonstrating a diphasic worsening of FOG after levodopa dosing. Cases Two PD patients with FOG were examined during the practically defined off state, the transition from off to on (15 and 22 minutes postdose), and in the full on state (45 and 60 minutes postdose). FOG was measured using Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III, item 11: freezing of gait. Both patients experienced worsening of FOG during the transition followed by improvement during the on state. Case 1 had serum levodopa levels measured. Videos are provided. Conclusions To our knowledge, this diphasic pattern of worsening of FOG has not been previously reported. The cause of this phenomenon is unknown but may relate to an inhibitory action of subthreshold levels of levodopa.

引用

收藏

页码：325 / 328

页数：4

相关论文

共 10 条

[1] Subthalamic Activity During Diphasic Dyskinesias in Parkinson's Disease [J].

Alegre, Manuel ;

Lopez-Azcarate, Jon ;

Alonso-Frech, Fernando ;

Rodriguez-Oroz, Maria C. ;

Valencia, Miguel ;

Guridi, Jorge ;

Artieda, Julio ;

Obeso, Jose A. .

MOVEMENT DISORDERS, 2012, 27 (09) :1176-1179

[2] Prevalence and associated features of self-reported freezing of gait in Parkinson disease: The DEEP FOG study [J].

Amboni, M. ;

Stocchi, F. ;

Abbruzzese, G. ;

Morgante, L. ;

Onofrj, M. ;

Ruggieri, S. ;

Tinazzi, M. ;

Zappia, M. ;

Attar, M. ;

Colombo, D. ;

Simoni, L. ;

Ori, A. ;

Barone, P. ;

Antonini, A. .

PARKINSONISM & RELATED DISORDERS, 2015, 21 (06) :644-649

[3] Falls and freezing of gait in Parkinson's disease: A review of two interconnected, episodic phenomena [J].

Bloem, BR ;

Hausdorff, JA ;

Visser, JE ;

Giladi, N .

MOVEMENT DISORDERS, 2004, 19 (08) :871-884

[4] "On" state freezing of gait in Parkinson disease A paradoxical levodopa-induced complication [J].

Espay, A. J. ;

Fasano, A. ;

van Nuenen, B. F. L. ;

Payne, M. M. ;

Snijders, A. H. ;

Bloem, B. R. .

NEUROLOGY, 2012, 78 (07) :454-457

[5] Levodopa-induced dyskinesia in Parkinson disease: Current and evolving concepts [J].

Espay, Alberto J. ;

Morgante, Francesca ;

Merola, Aristide ;

Fasano, Alfonso ;

Marsili, Luca ;

Fox, Susan H. ;

Bezard, Erwan ;

Picconi, Barbara ;

Calabresi, Paolo ;

Lang, Anthony E. .

ANNALS OF NEUROLOGY, 2018, 84 (06) :797-811

[6] Freezing of gait subtypes have different Parkinson's disease [J].

Factor, S. A. ;

Scullin, M. K. ;

Sollinger, A. B. ;

Land, J. O. ;

Wood-Siverio, C. ;

Zanders, L. ;

Freeman, A. ;

Bliwise, D. L. ;

Goldstein, F. C. .

PARKINSONISM & RELATED DISORDERS, 2014, 20 (12) :1359-1364

[7] Freezing of gait before the introduction of levodopa [J].

Koehler, Peter J. ;

Nonnekes, Jorik ;

Bloem, Bastiaan R. .

LANCET NEUROLOGY, 2021, 20 (02) :97-97

[8] Freezing of Gait can persist after an acute levodopa challenge in Parkinson's disease [J].

McKay, J. Lucas ;

Goldstein, Felicia C. ;

Sommerfeld, Barbara ;

Bernhard, Douglas ;

Parra, Sahyli Perez ;

Factor, Stewart A. .

NPJ PARKINSONS DISEASE, 2019, 5 (1)

[9] DOES AN INHIBITORY-ACTION OF LEVODOPA CONTRIBUTE TO MOTOR FLUCTUATIONS [J].

NUTT, JG ;

GANCHER, ST ;

WOODWARD, WR .

NEUROLOGY, 1988, 38 (10) :1553-1557

[10]

NUTT JG, 1990, NEUROLOGY, V40, P340