Tumor necrosis factor-α in low doses preactivates and activates macrophages by increasing their ability to produce reactive oxygen species and oxidize low-density lipoproteins:: protective effect of antioxidants

被引：3

作者：

Bilenko, MV ^{[1
]}

Khil'chenko, AV ^{[1
]}

Shmit'ko, NA ^{[1
]}

机构：

[1] Russian Acad Med Sci, VN Orekhovich Inst Biomed Chem, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 04期

关键词：

macrophages; low-density lipoproteins; chemiluminescence; electrophoresis; antioxidants;

D O I：

10.1023/A:1024656613633

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tumor necrosis factor-alpha in low doses activated rat peritoneal macrophages and intensified production of reactive oxygen species (zymosan-depended chemiluminescence). Single or 2-fold incubation with tumor necrosis factor-alpha activated and preactivated human blood macrophages and promoted oxidative modification of low-density lipoproteins (increased their mobility in agarose gel). Antioxidants (potassium phenosan, probucol, and desferal) suppressed oxidative modification of low-density lipoproteins induced by nonactivated, preactivated, and activated macrophages. Our results show that antioxidants hold much promise for the prevention and therapy of atherosclerosis.

引用

页码：349 / 352

页数：4