Evolution of Clinical Proteomics and its Role in Medicine

被引：46
作者：
Boja, Emily [1 ]
Hiltke, Tara [1 ]
Rivers, Robert [1 ]
Kinsinger, Christopher [1 ]
Rahbar, Amir [1 ]
Mesri, Mehdi [1 ]
Rodriguez, Henry [1 ]
机构：
[1] NCI, Off Canc Clin Prote Res, Ctr Strateg Sci Initiat, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF PROTEOME RESEARCH | 2011年 / 10卷 / 01期
关键词：
biomarker; clinical proteomics; protein quantitation; post-translational modifications; multiple reaction monitoring mass spectrometry; enzyme-linked immunosorbent assay; immunohistochemistry; flow cytometry; nanotechnology; verification; qualification; genomics; The Cancer Genome Atlas; TANDEM MASS-SPECTROMETRY; CODED AFFINITY TAGS; ISOBARIC TAGGING REAGENTS; COMPLEX PROTEIN MIXTURES; LABEL-FREE; QUANTITATIVE PROTEOMICS; BIOMARKER DISCOVERY; ABSOLUTE QUANTIFICATION; 2-DIMENSIONAL ELECTROPHORESIS; PEPTIDE IDENTIFICATION;
D O I：
10.1021/pr100532g
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Significant progress has been made in characterizing and sequencing genomic alterations of biospecimens from several types of cancer. Understanding the functional changes in the human proteome that arise from the genomic alterations or other factors is the next logical step in the development of high-value protein biomarkers that can be transitioned to clinical studies for biomarker qualification. Linking advances in genomic analysis to proteomic analysis will provide a pathway for qualified biomarkers which can drive the rational development of new diagnostics and therapies. The availability of these multidimensional data to the scientific community sets the stage for the development of new molecularly targeted cancer interventions.
引用
收藏
页码：66 / 84
页数：19
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