Metabolic Syndrome Individuals With and Without Type 2 Diabetes Mellitus Present Generalized Vascular Dysfunction Cross-Sectional Study

被引:94
作者
Waither, Guillaume [1 ]
Obert, Philippe [1 ,5 ]
Dutheil, Frederic [2 ,3 ,5 ]
Chapier, Robert [4 ]
Lesourd, Bruno [2 ,3 ]
Naughton, Geraldine [5 ]
Courteix, Daniel [2 ,5 ]
Vinet, Agnes [1 ]
机构
[1] Avignon Univ, LAPEC, EA4278, F-84000 Avignon, France
[2] Univ Blaise Pascal, Lab Metab Adaptat Exercise Physiol & Pathol Condi, EA3533, Clermont Ferrand, France
[3] Univ Hosp Clermont Ferrand CHU, Clermont Ferrand, France
[4] Omental Thermalia Ctr, Chatelguyon, France
[5] Australian Catholic Univ, Sch Exercise Sci, Melbourne, Vic, Australia
关键词
endothelial function; macrocirculation; metabolic syndrome; microcirculation; smooth muscle function; FLOW-MEDIATED VASODILATION; INSULIN-RESISTANCE; ENDOTHELIAL FUNCTION; BRACHIAL-ARTERY; MICROVASCULAR DYSFUNCTION; BLOOD-PRESSURE; NITRIC-OXIDE; REACTIVITY; EXERCISE; HYPEREMIA;
D O I
10.1161/ATVBAHA.114.304591
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives-The first objective of this study was to demonstrate differences within endothelial-dependent and endothelial-independent vasoreactivity in macro-and microcirculation beds among patients with metabolic syndrome (MetS) with and without type 2 diabetes mellitus (T2D) compared with healthy counterparts. The second objective was to determine relationships among the function of macro-and microvascular systems and abdominal adiposity, as well as inflammatory markers in the 3 groups. Approach and Results-Cross-sectional analyses of 53 patients with MetS without T2D and 25 with T2D, as well as aged 40 years and sex-matched healthy controls included microvascular (cutaneous blood flow measured with laser Doppler flowmetry in response to iontophoresis of acetylcholine and sodium nitroprusside), and macrovascular reactivity (flow-mediated dilation and nitrate-mediated dilation) along with anthropometric measures, plasma glucose, and insulin and inflammatory markers. Compared with controls, MetS participants showed depressed endothelial function of both microand macrocirculation beds. T2D in patients with MetS revealed an exacerbated vascular smooth muscle dysfunction in micro-and macrocirculation compared with MetS without T2D. Indices of micro-and macrocirculation were predominantly inversely related to abdominal fat and inflammatory markers. Conclusions-MetS was associated with endothelial-dependent and endothelial-independent dysfunction, affecting both the macro-and the microvascular systems. Participants with diabetes mellitus demonstrated the most severe smooth muscle dysfunction. The presence of central abdominal fat and systemic inflammation seems implicated in the pathogenesis of vascular dysfunctions in MetS.
引用
收藏
页码:1022 / U318
页数:13
相关论文
共 46 条
  • [1] Nitroglycerin-mediated vasodilatation of the brachial artery may predict long-term cardiovascular events irrespective of the presence of atherosclerotic disease
    Akamatsu, Daijirou
    Sato, Akira
    Goto, Hitoshi
    Watanabe, Tetsuo
    Hashimoto, Munetaka
    Shimizu, Takuya
    Sugawara, Hirofumi
    Sato, Hiroko
    Nakano, Yoshiyuki
    Miura, Teiji
    Zukeran, Tsutomu
    Serizawa, Fukashi
    Hamada, Yow
    Tsuchida, Ken
    Tsuji, Ichiro
    Satomi, Susumu
    [J]. JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2010, 17 (12) : 1266 - 1274
  • [2] The metabolic syndrome - a new worldwide definition
    Alberti, KGMM
    Zimmet, P
    Shaw, J
    [J]. LANCET, 2005, 366 (9491) : 1059 - 1062
  • [3] Bahia Luciana, 2006, Clinics, V61, P433, DOI 10.1590/S1807-59322006000500010
  • [4] Oral sildenafil increases skin hyperaemia induced by iontophoresis of sodium nitroprusside in healthy volunteers
    Blaise, S.
    Hellmann, M.
    Roustit, M.
    Isnard, S.
    Cracowski, J. L.
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2010, 160 (05) : 1128 - 1134
  • [5] Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery - A report of the International Brachial Artery Reactivity Task Force
    Corretti, MC
    Anderson, TJ
    Benjamin, EJ
    Celermajer, D
    Charbonneau, F
    Creager, MA
    Deanfield, J
    Drexler, H
    Gerhard-Herman, M
    Herrington, D
    Vallance, P
    Vita, J
    Vogel, R
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (02) : 257 - 265
  • [6] Metabolic syndrome in relation to structure and function of large arteries:: A predominant effect of blood pressure -: A report from the SU.VI.MAX. vascular study
    Czernichow, S
    Bertrais, S
    Blacher, J
    Oppert, JM
    Galan, P
    Ducimetière, P
    Hercberg, S
    Safar, M
    Zureik, M
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2005, 18 (09) : 1154 - 1160
  • [7] Macrovascular and microvascular dysfunction in the metabolic syndrome
    Czernichow, Sebastien
    Greenfield, Jerry R.
    Galan, Pilar
    Jellouli, Fatima
    Safar, Michel E.
    Blacher, Jacques
    Hercberg, Serge
    Levy, Bernard I.
    [J]. HYPERTENSION RESEARCH, 2010, 33 (04) : 293 - 297
  • [8] Noninvasive Assessment of Endothelial Function in the Skin Microcirculation
    Debbabi, Haythem
    Bonnin, Philippe
    Ducluzeau, Pierre Henri
    Leftheriotis, Georges
    Levy, Bernard I.
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2010, 23 (05) : 541 - 546
  • [9] Effects of Diabetes and Obesity on Vascular Reactivity, Inflammatory Cytokines, and Growth Factors
    Doupis, John
    Rahangdale, Shilpa
    Gnardellis, Charalambos
    Pena, Salvador E.
    Malhotra, Atul
    Veves, Aristidis
    [J]. OBESITY, 2011, 19 (04) : 729 - 735
  • [10] Different modalities of exercise to reduce visceral fat mass and cardiovascular risk in metabolic syndrome: the RESOLVE* randomized trial
    Dutheil, Frederic
    Lac, Gerard
    Lesourd, Bruno
    Chapier, Robert
    Walther, Guillaume
    Vinet, Agnes
    Sapin, Vincent
    Verney, Julien
    Ouchchane, Lemlih
    Duclos, Martine
    Obert, Philippe
    Courteix, Daniel
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 168 (04) : 3634 - 3642