Synthesis and Biological Evaluation of Quinoline-Based Novel Aurones

被引：39
作者：
Kumar, Gourav [1 ]
Lathwal, Ekta [1 ]
Saroha, Bhavna [1 ]
Kumar, Sanjeev [1 ]
Kumar, Suresh [1 ]
Chauhan, Nar Singh [2 ]
Kumar, Tarun [2 ]
机构：
[1] Kurukshetra Univ, Dept Chem, Kurukshetra 136119, Haryana, India
[2] Maharshi Dayanand Univ, Dept Biochem, Rohtak 124001, Haryana, India
来源：
CHEMISTRYSELECT | 2020年 / 5卷 / 12期
关键词：
Aurone; Benzofuran-3(2H)-one; 2-Chloroquinoline-3-carbaldehyde; Heterocycles; Solid-phase synthesis; ONE-POT; ANTICANCER; DERIVATIVES; INHIBITORS; SCAFFOLD; ANALOGS; DESIGN;
D O I：
10.1002/slct.201904912
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new series of quinoline based aurones 7(a-n) has been synthesized and evaluated for their antibacterial, antifungal and antiquorum sensing activities. These novel aurones have been prepared directly from 2-chloro-1-(2,4-dihydroxyphenyl)ethan-1-one in one pot, by reacting it with differently substituted 2-chloroquinoline-3-carbaldehydes using activated barium hydroxide under solvent free grinding conditions. Structures of these novel aurones are in agreement with their IR, H-1-NMR, C-13-NMR and HRMS data. Some of these compounds have attributed a significant antiquorum sensing activity.
引用
收藏
页码：3539 / 3543
页数：5
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