Synthesis and Biological Evaluation of Quinoline-Based Novel Aurones

被引：39

作者：

Kumar, Gourav ^{[1
]}

Lathwal, Ekta ^{[1
]}

Saroha, Bhavna ^{[1
]}

Kumar, Sanjeev ^{[1
]}

Kumar, Suresh ^{[1
]}

Chauhan, Nar Singh ^{[2
]}

Kumar, Tarun ^{[2
]}

机构：

[1] Kurukshetra Univ, Dept Chem, Kurukshetra 136119, Haryana, India

[2] Maharshi Dayanand Univ, Dept Biochem, Rohtak 124001, Haryana, India

来源：

CHEMISTRYSELECT | 2020年 / 5卷 / 12期

关键词：

Aurone; Benzofuran-3(2H)-one; 2-Chloroquinoline-3-carbaldehyde; Heterocycles; Solid-phase synthesis; ONE-POT; ANTICANCER; DERIVATIVES; INHIBITORS; SCAFFOLD; ANALOGS; DESIGN;

D O I：

10.1002/slct.201904912

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of quinoline based aurones 7(a-n) has been synthesized and evaluated for their antibacterial, antifungal and antiquorum sensing activities. These novel aurones have been prepared directly from 2-chloro-1-(2,4-dihydroxyphenyl)ethan-1-one in one pot, by reacting it with differently substituted 2-chloroquinoline-3-carbaldehydes using activated barium hydroxide under solvent free grinding conditions. Structures of these novel aurones are in agreement with their IR, H-1-NMR, C-13-NMR and HRMS data. Some of these compounds have attributed a significant antiquorum sensing activity.

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页码：3539 / 3543

页数：5

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