Photoactivatable and Cell-Membrane-Permeable Phosphatidylinositol 3,4,5-Trisphosphate

被引：60

作者：

Mentel, Matthias ^{[1
]}

Laketa, Vibor ^{[1
]}

Subramanian, Devaraj ^{[1
]}

Gillandt, Hartmut ^{[2
]}

Schultz, Carsten ^{[1
]}

机构：

[1] European Mol Biol Lab, Cell Biol & Biophys Unit, D-69117 Heidelberg, Germany

[2] Sirius Fine Chem SiChem GmbH, D-28359 Bremen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 16期

关键词：

caged compounds; phospholipids; kinases; signal transduction; PHOSPHOINOSITIDES; ACTIVATION; PHOSPHATE;

D O I：

10.1002/anie.201007796

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Unleashed inside cells: The signaling molecule PI(3,4,5)P3 is prepared in a form that allows its cellular uptake and subsequent activation by light (see picture). The rapid eight-step synthetic sequence yields a stable derivative of the signaling molecule with high biological activity after deprotection ("uncaging") with a laser flash, in live cells. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3811 / 3814

页数：4

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