IL28B polymorphisms and chronic hepatitis C

被引：14

作者：

Chevaliez, S. ^{[2
,3
]}

Hezode, C. ^{[1
,2
]}

机构：

[1] Univ Paris Est Creteil, Hop Henri Mondor, Dept Hepatol, F-94010 Creteil, France

[2] Hop Henri Mondor, INSERM, U955, F-94010 Creteil, France

[3] Univ Paris Est Creteil, Hop Henri Mondor, Dept Virol, French Natl Reference Ctr Viral Hepatitis B C & D, F-94010 Creteil, France

来源：

GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE | 2010年 / 34卷 / 11期

关键词：

PEGYLATED INTERFERON-ALPHA; RIBAVIRIN THERAPY; GENETIC-VARIATION; INFECTION; CLEARANCE; VIRUS;

D O I：

10.1016/j.gcb.2010.06.008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Human genetic factors that influence HCV treatment responses have been identified by a recent landmark discovery. A SNP has been identified (rs12979860) located in chromosome 19,3 kb upstream of the IL28B gene that encodes IFN-lambda 3, which was strongly associated with the sustained virological response (SVR) to pegIFN and ribavirin in more than 1000 patients with genotype 1 chronic hepatitis C. In patients of European ancestry, as well as in African-American and Hispanic patients, the CC genotype was associated with a two-fold greater SVR rate than the TT genotype, CT being closer to TT than to CC. More information is now needed to understand the mechanisms that underlie this association. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：587 / 589

页数：3

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