Association of four CpG-SNPs in the vascular-related genes with coronary heart disease

被引：10
作者：
Xu, Leiting [1 ]
Chen, Xiaoying [1 ]
Ye, Huadan [1 ]
Hong, Qingxiao [1 ]
Xu, Mingqing [2 ]
Duan, Shiwei [1 ]
机构：
[1] Ningbo Univ, Sch Med, Zhejiang Prov Key Lab Pathophysiol, Ningbo 315211, Zhejiang, Peoples R China
[2] Shanghai Jiao Tong Univ, BioX Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2015年 / 70卷
基金：
中国国家自然科学基金;
关键词：
Coronary heart disease; CpG-SNPs; Polymorphism; ANGIOTENSIN-CONVERTING ENZYME; HUMAN CYSTATIN-C; ARTERY-DISEASE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; TOTAL CHOLESTEROL; RISK-FACTORS; FOLLOW-UP; POLYMORPHISM;
D O I：
10.1016/j.biopha.2015.01.014
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Vascular-related gene polymorphism can affect the susceptibility of coronary heart disease. In current study, we aimed to evaluate the contribution of four vascular-related gene CpG-SNPs to coronary heart disease (CHD). A total of 784 angiography-proven CHD patients and 746 non-CHD controls were included in the current association study. The four CpG-SNPs (including VEGFA rs1005230, ACE rs4316, CST3 rs3827143 and AGTR1 rs275653) were genotyped using the Sequenom MassARRAY platform. All genotype distribution of four SNPs met HWE. Among the four CpG-SNPs, none was found to be associated with CHD on both genotype and allele levels. Further subgroup tests by age or gender were unable to observe any significant associations of them with CHD. Our case-control study showed that none of four CpG-SNPs in the vascular-related genes was associated with the risk of CHD in Han Chinese, although we could not exclude other genetic variants of these vascular-related genes with contribution to CHD. (C) 2015 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：80 / 83
页数：4
相关论文
共 44 条
  • [1] Renin-angiotensin system genes polymorphism in Egyptians with premature coronary artery disease
    Abd El-Aziz, Tarek A.
    Hussein, Yousri M.
    Mohamed, Randa H.
    Shalaby, Sally M.
    [J]. GENE, 2012, 498 (02) : 270 - 275
  • [2] THE HUMAN CYSTATIN-C GENE (CST3), MUTATED IN HEREDITARY CYSTATIN-C AMYLOID ANGIOPATHY, IS LOCATED ON CHROMOSOME-20
    ABRAHAMSON, M
    ISLAM, MQ
    SZPIRER, J
    SZPIRER, C
    LEVAN, G
    [J]. HUMAN GENETICS, 1989, 82 (03) : 223 - 226
  • [3] The primary and secondary prevention of coronary artery disease
    Becker, Richard C.
    Meade, Thomas W.
    Berger, Peter B.
    Ezekowitz, Michael
    O'Connor, Christopher M.
    Vorchheimer, David A.
    Guyatt, Gordon H.
    Mark, Daniel B.
    Harrington, Robert A.
    [J]. CHEST, 2008, 133 (06) : 776S - 814S
  • [4] Angiotensin converting enzyme gene polymorphism is associated with severity of coronary artery disease in men with high total cholesterol levels
    Borzyszkowska, Joanna
    Stanislawska-Sachadyn, Anna
    Wirtwein, Marcin
    Sobiczewski, Wojciech
    Ciecwierz, Dariusz
    Targonski, Radoslaw
    Gruchala, Marcin
    Rynkiewicz, Andrzej
    Limon, Janusz
    [J]. JOURNAL OF APPLIED GENETICS, 2012, 53 (02) : 175 - 182
  • [5] RELATION OF SERUM TOTAL CHOLESTEROL AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL PERCENTAGE TO THE INCIDENCE OF DEFINITE CORONARY EVENTS - 20-YEAR FOLLOW-UP OF THE DONOLO-TEL-AVIV PROSPECTIVE CORONARY-ARTERY DISEASE STUDY
    BRUNNER, D
    WEISBORT, J
    MESHULAM, N
    SCHWARTZ, S
    GROSS, J
    SALTZRENNERT, H
    ALTMAN, S
    LOEBL, K
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1987, 59 (15) : 1271 - 1276
  • [6] DELETION POLYMORPHISM IN THE GENE FOR ANGIOTENSIN-CONVERTING ENZYME IS A POTENT RISK FACTOR FOR MYOCARDIAL-INFARCTION
    CAMBIEN, F
    POIRIER, O
    LECERF, L
    EVANS, A
    CAMBOU, JP
    ARVEILER, D
    LUC, G
    BARD, JM
    BARA, L
    RICARD, S
    TIRET, L
    AMOUYEL, P
    ALHENCGELAS, F
    SOUBRIER, F
    [J]. NATURE, 1992, 359 (6396) : 641 - 644
  • [7] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets
    Dayeh, T. A.
    Olsson, A. H.
    Volkov, P.
    Almgren, P.
    Ronn, T.
    Ling, C.
    [J]. DIABETOLOGIA, 2013, 56 (05) : 1036 - 1046
  • [8] Kidney dysfunction and fatal cardiovascular disease - an association independent of atherosclerotic events: Results from the Health, Aging, and Body Composition (Health ABC) study
    Deo, Rajat
    Fyr, Christina L. Wassel
    Fried, Linda F.
    Newman, Anne B.
    Harris, Tamara B.
    Angleman, Sara
    Green, Christie
    Kritchevsky, Stephen B.
    Chertow, Glenn M.
    Cummings, Steven R.
    Shlipak, Michael G.
    [J]. AMERICAN HEART JOURNAL, 2008, 155 (01) : 62 - 68
  • [9] The effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study
    Do, Anh N.
    Irvin, Marguerite R.
    Lynch, Amy I.
    Claas, Steven A.
    Boerwinkle, Eric
    Davis, Barry R.
    Ford, Charles E.
    Eckfeldt, John H.
    Tiwari, Hemant K.
    Limdi, Nita A.
    Arnett, Donna K.
    [J]. FRONTIERS IN PHARMACOLOGY, 2014, 5
  • [10] Prospective association of vascular endothelial growth factor-A (VEGF-A) with coronary heart disease mortality in Southeastern New England
    Eaton, Charles B.
    Gramling, Robert
    Parker, Donna R.
    Roberts, Mary B.
    Lu, Bing
    Ridker, Paul M.
    [J]. ATHEROSCLEROSIS, 2008, 200 (01) : 221 - 227
12345