Curcumin-loaded chitosan/carboxymethyl starch/montmorillonite bio-nanocomposite for reduction of dental bacterial biofilm formation

被引：84
作者：
Jahanizadeh, Shabnam [1 ]
Yazdian, Fatemeh [2 ]
Marjani, Azam [1 ]
Omidi, Meisam [3 ]
Rashedi, Hamid [4 ]
机构：
[1] Islamic Azad Univ, Arak Branch, Dept Chem, Arak, Iran
[2] Univ Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Tehran, Iran
[3] Shahid Beheshti Univ, Prot Res Ctr, GC, Tehran, Iran
[4] Univ Tehran, Sch Chem Engn, Dept Biotechnol, Coll Engn, Tehran, Iran
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2017年 / 105卷
关键词：
Curcumin; Polysaccharide; Streptococcus mutans; STREPTOCOCCUS-MUTANS; IN-VIVO; NANOPARTICLES; STARCH; DELIVERY; MICROSPHERES; OPTIMIZATION; FILMS;
D O I：
10.1016/j.ijbiomac.2017.07.101
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel bio nanocomposite of Carboxymethyl Starch (CMS)-Chitosan (CS)-Montmorillonite (MMT) was developed for Curcumin delivery. To improve Curcumin entrapment into Cs-CMS-MMT, different ratios of Chitosan (Cs), Carboxymethyl Starch (CMS) and MMT were used. Particle size and Curcumin entrapment efficiency (EE) were highly affected by different formulation variables. Polysaccharide concentration, Cs-CMS ratio and sonication time had significant effect on particle size. MMT addition enhanced the entrapment efficiency. To optimize entrapment efficiency of Curcumin, statistical analysis was used, and an experiment based on screening design performed with two variants. Morphology and structural characterization of nanocomposite and Curcumin entrapment efficiency were analyzed. The optimal formulation had the average particles size of 35.9 nm with Curcumin entrapment efficiency of 91%. Finally, the antibacterial activity of bio nanocomposite against Streptococcus mutans was assessed. Curcumin-loaded bio nanocomposite hindered the formation of biofilm on dental models very effectively. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：757 / 763
页数：7
相关论文
共 38 条
[1]   Efficient water soluble O-carboxymethyl chitosan nanocarrier for the delivery of curcumin to cancer cells [J].
Anitha, A. ;
Maya, S. ;
Deepa, N. ;
Chennazhi, K. P. ;
Nair, S. V. ;
Tamura, H. ;
Jayakumar, R. .
CARBOHYDRATE POLYMERS, 2011, 83 (02) :452-461
[2]  
[Anonymous], 2013, Performance Standards for Antimicrobial Susceptibility Testing. Twenty-Third Informational Supplement (CLSI Document M100-S23), V33, P1
[3]   Curcumin Nanoparticles: Preparation, Characterization, and Antimicrobial Study [J].
Bhawana ;
Basniwal, Rupesh Kumar ;
Buttar, Harpreet Singh ;
Jain, V. K. ;
Jain, Nidhi .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (05) :2056-2061
[4]   Role of HtrA in surface protein expression and biofilm formation by Streptococcus mutans [J].
Biswas, S ;
Biswas, I .
INFECTION AND IMMUNITY, 2005, 73 (10) :6923-6934
[5]   Physical and mechanical properties of thermoplastic starch/montmorillonite nanocomposite films [J].
Cyras, Viviana P. ;
Manfredi, Liliana B. ;
Ton-That, Minh-Tan ;
Vazquez, Analia .
CARBOHYDRATE POLYMERS, 2008, 73 (01) :55-63
[6]   Antimicrobial Effect of Chitosan Nanoparticles on Streptococcus mutans Biofilms [J].
de Paz, Luis E. Chavez ;
Resin, Anton ;
Howard, Kenneth A. ;
Sutherland, Duncan S. ;
Wejse, Peter L. .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2011, 77 (11) :3892-3895
[7]   Chitosan-Montmorillonite microspheres: A sustainable fertilizer delivery system [J].
dos Santos, Bruna Rodrigues ;
Bacalhau, Fabiana Britti ;
Pereira, Tamires dos Santos ;
Souza, Claudinei Fonseca ;
Faez, Roselena .
CARBOHYDRATE POLYMERS, 2015, 127 :340-346
[8]   pH-sensitive micelles based on acid-labile pluronic F68-curcumin conjugates for improved tumor intracellular drug delivery [J].
Fang, Xiao-Bin ;
Zhang, Jin-Ming ;
Xie, Xi ;
Liu, Di ;
He, Cheng-Wei ;
Wan, Jian-Bo ;
Chen, Mei-Wan .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 502 (1-2) :28-37
[9]  
Fathy M., THESIS, P20151
[10]   Drug Delivery Systems for Dental Applications [J].
Ficai, Denisa ;
Sandulescu, Mihai ;
Ficai, Anton ;
Andronescu, Ecaterina ;
Yetmez, Mehmet ;
Agrali, Omer B. ;
Elemek, Eser ;
Gunduz, Oguzhan ;
Sahin, Yesim M. ;
Oktar, Faik N. .
CURRENT ORGANIC CHEMISTRY, 2017, 21 (01) :64-73
1234