Non-alcoholic fatty liver disease and risk of cardiovascular disease

被引：178
作者：
Lonardo, Amedeo [1 ,2 ,3 ]
Sookoian, Silvia [4 ]
Pirola, Carlos J. [5 ]
Targher, Giovanni
机构：
[1] Azienda USL, NOCSAE, Dept Biomed Metab & Neural Sci, Outpatient Liver Clin, Modena, Italy
[2] Azienda USL, NOCSAE, Dept Biomed Metab & Neural Sci, Div Internal Med, Modena, Italy
[3] Univ Modena & Reggio Emilia, Modena, Italy
[4] Univ Buenos Aires, Nat Sci & Tech Res Council CONICET, Inst Med Res A Lanari IDIM, Dept Clin & Mol Hepatol, Buenos Aires, DF, Argentina
[5] Univ Buenos Aires, Nat Sci & Tech Res Council CONICET, Inst Med Res A Lanari IDIM, Dept Mol Genet & Biol Complex Dis, Buenos Aires, DF, Argentina
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 2016年 / 65卷 / 08期
关键词：
NAFLD; CVD; Cardiovascular risk; GAMMA-GLUTAMYL-TRANSFERASE; CORONARY-HEART-DISEASE; SUPERFAMILY MEMBER 2; TERM-FOLLOW-UP; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; INSULIN-RESISTANCE; DIABETES-MELLITUS; CONFERS SUSCEPTIBILITY; ATRIAL-FIBRILLATION;
D O I：
10.1016/j.metabol.2015.09.017
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide, causing considerable liver-related mortality and morbidity. During the past decade, it has also become increasingly evident that NAFLD is a multisystem disease that affects many extra-hepatic organ systems, including the heart and the vascular system. In this updated clinical review, we discuss the rapidly expanding body of clinical and epidemiological evidence that supports a strong association of NAFLD with cardiovascular diseases (CVDs) and other functional and structural myocardial abnormalities. We also discuss some recently published data that correlate NAFLD due to specific genetic polymorphisms with the risk of CVDs. Finally, we briefly examine the assessment tools for estimating the global CVD risk in patients with NAFLD as well as the conventional and the more innovative pharmacological approaches for the treatment of CVD risk in this group of patients. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：1136 / 1150
页数：15
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