A novel method for the mild and selective amidation of diesters and the amidation of monoesters

被引：40

作者：

Guo, ZR ^{[1
]}

Dowdy, ED ^{[1
]}

Li, WS ^{[1
]}

Polniaszek, R ^{[1
]}

Delaney, E ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Proc Res & Dev, New Brunswick, NJ 08903 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期

关键词：

selective amidation of diesters; amidation of esters; Lewis acids;

D O I：

10.1016/S0040-4039(01)00079-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selective monoamidation of diesters and amidation of esters mediated by Lewis acids are described. The selective amidations of dimethyl pyridine-2,5-dicarboxylate (I) and dimethyl 2,3-indole-dicarboxylate (4) with primary and secondary amines mediated by MgCl2 or MgBr2 under mild conditions gave the corresponding ester-amides in high yield. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：1843 / 1845

页数：3

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