Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997-2015: a systematic review of individual case data

被引:198
作者
Lai, Shengjie [1 ,2 ,3 ]
Qin, Ying [1 ]
Cowling, Benjamin J. [4 ]
Ren, Xiang [1 ]
Wardrop, Nicola A. [2 ,3 ]
Gilbert, Marius [5 ,6 ]
Tsang, Tim K. [4 ]
Wu, Peng [4 ]
Feng, Luzhao [1 ]
Jiang, Hui [1 ]
Peng, Zhibin [1 ]
Zheng, Jiandong [1 ]
Liao, Qiaohong [1 ]
Li, Sa [1 ]
Horby, Peter W. [7 ,8 ,9 ]
Farrar, Jeremy J. [7 ,8 ,9 ,10 ]
Gao, George F. [11 ,12 ]
Tatem, Andrew J. [2 ,13 ]
Yu, Hongjie [1 ,14 ]
机构
[1] Chinese Ctr Dis Control & Prevent, Div Infect Dis, Key Lab Surveillance & Early Warning Infect Dis, Beijing, Peoples R China
[2] Univ Southampton, Dept Geog & Environm, Southampton, Hants, England
[3] Flowminder Fdn, Stockholm, Sweden
[4] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, WHO Collaborating Ctr Infect Dis Epidemiol & Cont, Hong Kong, Hong Kong, Peoples R China
[5] Univ Libre Bruxelles, Biol Control & Spatial Ecol, Brussels, Belgium
[6] Fonds Natl Rech Sci, Brussels, Belgium
[7] Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam
[8] Univ Oxford, Dept Clin Med, Ctr Trop Med Nuffield, Oxford, England
[9] Singapore Infect Dis Initiat, Singapore, Singapore
[10] Univ Oxford, Churchill Hosp, Int Severe Acute Resp & Emerging Infect Consortiu, Ctr Trop Med, Oxford, England
[11] Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China
[12] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China
[13] NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA
[14] Fudan Univ, Sch Publ Hlth, Minist Educ, Key Lab Publ Hlth Safety, Shanghai 200032, Peoples R China
基金
美国国家卫生研究院; 英国惠康基金; 英国医学研究理事会; 比尔及梅琳达.盖茨基金会;
关键词
TO-PERSON TRANSMISSION; RISK-FACTORS; HONG-KONG; A(H5N1); EGYPT; VACCINES; POULTRY; WORLDWIDE; EVOLUTION; H7N9;
D O I
10.1016/S1473-3099(16)00153-5
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Avian influenza A H5N1 viruses have caused many, typically severe, human infections since the first human case was reported in 1997. However, no comprehensive epidemiological analysis of global human cases of H5N1 from 1997 to 2015 exists. Moreover, few studies have examined in detail the changing epidemiology of human H5N1 cases in Egypt, especially given the outbreaks since November, 2014, which have the highest number of cases ever reported worldwide in a similar period. Data on individual patients were collated from different sources using a systematic approach to describe the global epidemiology of 907 human H5N1 cases between May, 1997, and April, 2015. The number of affected countries rose between 2003 and 2008, with expansion from east and southeast Asia, then to west Asia and Africa. Most cases (67.2%) occurred from December to March, and the overall case-fatality risk was 483 (53.5%) of 903 cases which varied across geographical regions. Although the incidence in Egypt has increased dramatically since November, 2014, compared with the cases beforehand, there were no significant differences in the fatality risk, history of exposure to poultry, history of patient contact, and time from onset to hospital admission in the recent cases.
引用
收藏
页码:E108 / E118
页数:11
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