FR131535, a novel water-soluble echinocandin-like lipopeptide: Synthesis and biological properties

被引：21

作者：

Fujie, A

Iwamoto, T

Sato, B

Muramatsu, H

Kasahara, C

Furuta, T

Hori, Y

Hino, M

Hashimoto, S

机构：

[1] Fujisawa Pharmaceut Co Ltd, Exploratory Res Labs, Tsukuba, Ibaraki 3002698, Japan

[2] Univ Tokyo, Inst Med Sci, Dept Parasitol, Minato Ku, Tokyo 1080071, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(00)00677-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological properties of a novel water-soluble echinocandin-like lipopeptide, FR131535, are described. This compound displayed potent in vitro and in vivo antifungal activities. The hemolytic activity of FR901379 was reduced by replacing the acyl side chain. This compound showed good water-solubility, comparable to the natural product FR901379. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：399 / 402

页数：4

共 16 条

[1]

AKAISHI S, 1974, YAKUJI, V16, P901

[2]

ANAISSIE E, 1989, REV INFECT DIS, V11, P369

[3] EMERGING FUNGAL PATHOGENS [J].