HbA1c and Glucose Management Indicator Discordance Associated with Obesity and Type 2 Diabetes in Intermittent Scanning Glucose Monitoring System

被引:6
作者
Fellinger, Paul [1 ]
Rodewald, Karin [1 ]
Ferch, Moritz [1 ]
Itariu, Bianca [1 ]
Kautzky-Willer, Alexandra [1 ]
Winhofer, Yvonne [1 ]
机构
[1] Div Endocrinol & Metab, Internal Med 3, Waehringer Guertel 18-20, A-1090 Vienna, Austria
来源
BIOSENSORS-BASEL | 2022年 / 12卷 / 05期
关键词
continuous glucose monitoring; GMI; HbA1c; type; 2; diabetes; overweight; HEMOGLOBIN A1C;
D O I
10.3390/bios12050288
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Glucose management indicator (GMI) is frequently used as a substitute for HbA1c, especially when using telemedicine. Discordances between GMI and HbA1c were previously mostly reported in populations with type 1 diabetes (T1DM) using real-time CGM. Our aim was to investigate the accordance between GMI and HbA1c in patients with diabetes using intermittent scanning CGM (isCGM). In this retrospective cross-sectional study, patients with diabetes who used isCGM >70% of the time of the investigated time periods were included. GMI of four different time spans (between 14 and 30 days), covering a period of 3 months, reflected by the HbA1c, were investigated. The influence of clinical- and isCGM-derived parameters on the discordance was assessed. We included 278 patients (55% T1DM; 33% type 2 diabetes (T2DM)) with a mean HbA1c of 7.63%. The mean GMI of the four time periods was between 7.19% and 7.25%. On average, the absolute deviation between the four calculated GMIs and HbA1c ranged from 0.6% to 0.65%. The discordance was greater with increased BMI, a diagnosis of T2DM, and a greater difference between the most recent GMI and GMI assessed 8 to 10 weeks prior to HbA1c assessment. Our data shows that, especially in patients with increased BMI and T2DM, this difference is more pronounced and should therefore be considered when making therapeutic decisions.
引用
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页数:9
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共 22 条
  • [11] Mensh Brett D, 2013, J Diabetes Sci Technol, V7, P863
  • [12] A Clinical Trial of the Accuracy and Treatment Experience of the Flash Glucose Monitor FreeStyle Libre in Adults with Type 1 Diabetes
    Olafsdottir, Arndis F.
    Attvall, Stig
    Sandgren, Ulrika
    Dahlqvist, Sofia
    Pivodic, Aldina
    Skrtic, Stanko
    Theodorsson, Elvar
    Lind, Marcus
    [J]. DIABETES TECHNOLOGY & THERAPEUTICS, 2017, 19 (03) : 164 - 172
  • [13] HbA1c and Glucose Management Indicator Discordance: A Real-World Analysis
    Perlman, Jordan E.
    Gooley, Theodore A.
    McNulty, Bridget
    Meyers, Jedidiah
    Hirsch, Irl B.
    [J]. DIABETES TECHNOLOGY & THERAPEUTICS, 2021, 23 (04) : 253 - 258
  • [14] MECHANISMS OF INSULIN ACTION AND INSULIN RESISTANCE
    Petersen, Max C.
    Shulman, Gerald I.
    [J]. PHYSIOLOGICAL REVIEWS, 2018, 98 (04) : 2133 - 2223
  • [15] The Effect of Body Fat, Aging, and Diabetes on Vertical and Shear Pressure in and Under a Waist Belt and Its Effect on Skin Blood Flow
    Petrofsky, Jerrold S.
    McLellan, Katie
    Prowse, Michelle
    Bains, Gurinder
    Berk, Lee
    Lee, Scott
    [J]. DIABETES TECHNOLOGY & THERAPEUTICS, 2010, 12 (02) : 153 - 160
  • [16] Time in Specific Glucose Ranges, Glucose Management Indicator, and Glycemic Variability: Impact of Continuous Glucose Monitoring (CGM) System Model and Sensor on CGM Metrics
    Pleus, Stefan
    Kamecke, Ulrike
    Waldenmaier, Delia
    Link, Manuela
    Zschornack, Eva
    Jendrike, Nina
    Haug, Cornelia
    Freckmann, Guido
    [J]. JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, 2021, 15 (05): : 1104 - 1110
  • [17] Time in range, as measured by continuous glucose monitor, as a predictor of microvascular complications in type 2 diabetes: a systematic review
    Raj, Rishi
    Mishra, Rahul
    Jha, Nivedita
    Joshi, Vivek
    Correa, Ricardo
    Kern, Philip A.
    [J]. BMJ OPEN DIABETES RESEARCH & CARE, 2022, 10 (01)
  • [18] Optimal Sampling Duration for Continuous Glucose Monitoring to Determine Long-Term Glycemic Control
    Riddlesworth, Tonya D.
    Beck, Roy W.
    Gal, Robin L.
    Connor, Crystal G.
    Bergenstal, Richard M.
    Lee, Sooji
    Willi, Steven M.
    [J]. DIABETES TECHNOLOGY & THERAPEUTICS, 2018, 20 (04) : 314 - 316
  • [19] Marked improvement in HbA1c following commencement of flash glucose monitoring in people with type 1 diabetes
    Tyndall, Victoria
    Stimson, Roland H.
    Zammitt, Nicola N.
    Ritchie, Stuart A.
    McKnight, John A.
    Dover, Anna R.
    Gibb, Fraser W.
    [J]. DIABETOLOGIA, 2019, 62 (08) : 1349 - 1356
  • [20] Metrics Beyond Hemoglobin A1C in Diabetes Management: Time in Range, Hypoglycemia, and Other Parameters
    Wright, Lorena Alarcon-Casas
    Hirsch, Irl B.
    [J]. DIABETES TECHNOLOGY & THERAPEUTICS, 2017, 19 : S16 - S26