Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children

被引：540

作者：

Blanton, Laura V. ^{[1
,2
]}

Charbonneau, Mark R. ^{[1
,2
]}

Salih, Tarek ^{[1
,2
]}

Barratt, Michael J. ^{[1
,2
]}

Venkatesh, Siddarth ^{[1
,2
]}

Ilkaveya, Olga ^{[3
,4
]}

Subramanian, Sathish ^{[1
,2
]}

Manary, Mark J. ^{[5
,6
]}

Trehan, Indi ^{[5
,7
]}

Jorgensen, Josh M. ^{[8
,9
]}

Fan, Yue-mei ^{[10
]}

Henrissat, Bernard ^{[11
,12
,13
]}

Leyn, Semen A. ^{[14
]}

Rodionov, Dmitry A. ^{[14
,15
]}

Osterman, Andrei L. ^{[15
]}

Maleta, KennethM. ^{[6
]}

Newgard, Christopher B. ^{[3
,4
,16
,17
]}

Ashorn, Per ^{[10
,18
]}

Dewey, Kathryn G. ^{[8
,9
]}

Gordon, Jeffrey I. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63108 USA

[2] Washington Univ, Sch Med, Ctr Gut Microbiome & Nutr Res, St Louis, MO 63108 USA

[3] Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC 27710 USA

[5] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[6] Univ Malawi, Sch Publ Hlth & Family Med, Coll Med, Blantyre 3, Malawi

[7] Univ Malawi, Dept Paediat & Child Hlth, Coll Med, Blantyre 3, Malawi

[8] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA

[9] Univ Calif Davis, Program Int & Community Nutr, Davis, CA 95616 USA

[10] Univ Tampere, Dept Int Hlth, Sch Med, Tampere 33014, Finland

[11] CNRS, Architecture & Fonct Macromol Biol, F-13288 Marseille 9, France

[12] Aix Marseille Univ, F-13288 Marseille 9, France

[13] King Abdulaziz Univ, Dept Biol Sci, Jeddah 21413, Saudi Arabia

[14] Russian Acad Sci, AA Kharkevich Inst Informat Transmiss Problems, Moscow 127994, Russia

[15] Sanford Burnham Prebys Med Discovery Inst, Infect & Inflammatory Dis Ctr, La Jolla, CA 92037 USA

[16] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[17] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[18] Tampere Univ Hosp, Dept Pediat, Tampere 33521, Finland

来源：

SCIENCE | 2016年 / 351卷 / 6275期

基金：

俄罗斯科学基金会; 芬兰科学院;

关键词：

ENVIRONMENTAL ENTERIC DYSFUNCTION; UNDERNUTRITION; MALNUTRITION;

D O I：

10.1126/science.aad3311

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Undernourished children exhibit impaired development of their gut microbiota. Transplanting microbiota from 6- and 18-month-old healthy or undernourished Malawian donors into young germ-free mice that were fed a Malawian diet revealed that immature microbiota from undernourished infants and children transmit impaired growth phenotypes. The representation of several age-discriminatory taxa in recipient animals correlated with lean body mass gain; liver, muscle, and brain metabolism; and bone morphology. Mice were cohoused shortly after receiving microbiota from healthy or severely stunted and underweight infants; age-and growth-discriminatory taxa from the microbiota of the former were able to invade that of the latter, which prevented growth impairments in recipient animals. Adding two invasive species, Ruminococcus gnavus and Clostridium symbiosum, to the microbiota from undernourished donors also ameliorated growth and metabolic abnormalities in recipient animals. These results provide evidence that microbiota immaturity is causally related to undernutrition and reveal potential therapeutic targets and agents.

引用

页数：7

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