Proteomic profiling of pancreatic cancer for biomarker discovery

被引：114
作者：
Chen, R
Pan, S
Brentnall, TA
Aebersold, R
机构：
[1] Univ Washington, Dept Med, GI Div, Seattle, WA 98195 USA
[2] Inst Syst Biol, Seattle, WA 98103 USA
[3] Swiss Fed Inst Technol, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland
[4] Univ Zurich, Sci Fed Inst, Fac Nat, CH-8093 Zurich, Switzerland
来源：
MOLECULAR & CELLULAR PROTEOMICS | 2005年 / 4卷 / 04期
关键词：
D O I：
10.1074/mcp.R500004-MCP200
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Pancreatic cancer is a uniformly lethal disease that is difficult to diagnose at early stage and even more difficult to cure. In recent years, there has been a substantial interest in applying proteomics technologies to identify protein biomarkers for early detection of cancer. Quantitative proteomic profiling of body fluids, tissues, or other biological samples to identify differentially expressed proteins represents a very promising approach for improving the outcome of this disease. Proteins associated with pancreatic cancer identified through proteomic profiling technologies could be useful as biomarkers for the early diagnosis, therapeutic targets, and disease response markers. In this article, we discuss recent progress and challenges for applying quantitative proteomics technologies for biomarker discovery in pancreatic cancer.
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收藏
页码：523 / 533
页数：11
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