Gas-Phase Synthesis of Pyrazolo[3,4-b]pyridin-4-ones

被引：7
|
作者：
Mackay, Martha [1 ]
Nortcliffe, Andrew [1 ]
McNab, Hamish [1 ]
Hulme, Alison N. [1 ]
机构：
[1] Univ Edinburgh, EastCHEM Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland
来源：
SYNTHESIS-STUTTGART | 2015年 / 47卷 / 02期
关键词：
gas-phase reactions; pericyclic reactions; heterocycles; Meldrum's acid; medicinal chemistry; BIOLOGICAL EVALUATION; INHIBITORS; POTENT; PYROLYSIS; ACID;
D O I：
10.1055/s-0034-1378666
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Flash vacuum pyrolysis (FVP) at 500-600 degrees C of 1-substituted pyrazolylaminomethylene derivatives of Meldrum's acid provides 1-substituted pyrazolo[3,4-b]pyridin-4-ones in high yields. If the 1-substituent is a tert-butyl group, FVP at 750-850 degrees C causes elimination of 2-methyl-1-propene to give the parent pyrazolo[3,4-b]pyridin-4-one.
引用
收藏
页码：242 / 248
页数：7
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