Susceptibility of Ph-Positive ALL to TKI Therapy Associated with BCR-ABL Rearrangement Patterns: A Retrospective Analysis

被引：2

作者：

Jing, Yu ^{[1
,2
]}

Chen, Huiren ^{[3
]}

Liu, Mingjuan ^{[1
,2
,4
]}

Zhou, Minhang ^{[1
,2
]}

Guo, Yuelu ^{[1
,2
]}

Gao, Chunji ^{[1
,2
]}

Wang, Quanshun ^{[1
,2
]}

Li, Honghua ^{[1
,2
]}

Zhao, Yu ^{[1
,2
]}

Bo, Jian ^{[1
,2
]}

Huang, Wenrong ^{[1
,2
]}

Zhu, Haiyan ^{[1
,2
]}

Zhang, Yongqing ^{[4
]}

Yu, Li ^{[1
,2
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Hematol, Beijing, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, BMT Ctr, Beijing, Peoples R China

[3] Gen Hosp Beijing Mil Reg, Dept Hematol, Beijing, Peoples R China

[4] 309th Hosp Chinese Peoples Liberat Army, Dept Hematol, Beijing, Peoples R China

来源：

PLOS ONE | 2014年 / 9卷 / 11期

基金：

中国国家自然科学基金;

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; STEM-CELL TRANSPLANTATION; CHRONIC MYELOID-LEUKEMIA; TYROSINE KINASE; ADULT PATIENTS; IMATINIB; CHEMOTHERAPY; COMBINATION; BREAKPOINT; MANAGEMENT;

D O I：

10.1371/journal.pone.0110431

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Tyrosine kinase inhibitors (TKIs) have demonstrated success in the treatment of acute lymphoblastic leukemia (ALL) in patients that express BCR-ABL rearrangements (Philadelphia chromosome [Ph]). The current study aimed to assess the efficacy of TKIs and prognostic factors in the treatment of adults with Ph+-ALL. Methods: In this multicenter retrospective study, the relationship between Ph+-ALL and treatment outcomes among Chinese patients receiving TKI-containing induction/consolidation chemotherapy was examined. A total of 86 Ph+-ALL patients were included and followed for 3.85 (0.43-9.30) years. Overall survival (OS) and event-free survival (EFS) were analyzed. Results: A total of 86 Ph+-ALL patients (40 females and 46 males; median age: 34.0 years) were enrolled, including those with BCR/ABL transcripts 190 (n=52), 210 (n=25), and 230 (n=2); BCR/ABL isoform determination was not available for 7 patients. Mortality was influenced by variable BCR/ABL transcripts and TKI administration, and BCR/ABL transcripts, hematopoietic stem cell transplantation (HSCT), and TKI administration were associated with the occurrence of events. The OS rate in the TKI administration group during steady state was significantly higher compared with those patients who did not receive TKI administration (P=0.008), the EFS rate in the TKI administration group during steady state was significantly higher compared with those patients who did not receive TKIs (P=0.012), and also higher than those with TKI salvage administration (P=0.004). BCR/ABL transcripts 210 showed preferable OS and EFS compared with BCR/ABL transcripts 190 and 230 (P<0.05 for each). Conclusions: The susceptibility of Ph+-ALL to TKI associated with the patterns of BCR-ABL rearrangement is demonstrated for the first time, thus adding another risk-stratifying molecular prognostic tool for the management of patients with Ph+-ALL.

引用

页数：14