Application of metabolomics in intrahepatic cholestasis of pregnancy: a systematic review

被引：8
作者：
Yang, Zhuoqiao [1 ]
Yao, Mengxin [1 ]
Zhang, Chunhua [2 ]
Hu, Xuan [1 ]
Zhong, Yi [1 ]
Xu, Xiangxiang [2 ]
Yin, Jieyun [1 ,3 ]
机构：
[1] Soochow Univ, Dept Epidemiol & Hlth Stat, Med Coll, Suzhou, Peoples R China
[2] Nanjing Med Univ, Suzhou Municipal Hosp, Dept Obstet, Gusu Sch,Affiliated Suzhou Hosp, Suzhou, Jiangsu, Peoples R China
[3] Soochow Univ, Sch Publ Hlth, Med Coll, 199 Renai Rd, Suzhou, Jiangsu, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2022年 / 27卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Intrahepatic cholestasis of pregnancy; Metabolomics; Metabolites; Bile Acids; BILE-ACID PROFILES; LIVER-INJURY; SERUM; PLASMA; WOMEN;
D O I：
10.1186/s40001-022-00802-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background Intrahepatic cholestasis of pregnancy (ICP) is a severe idiopathic disorder of bile metabolism; however, the etiology and pathogenesis of ICP remain unclear. Aims This study comprehensively reviewed metabolomics studies related to ICP, to help in identifying the pathophysiological changes of ICP and evaluating the potential application of metabolomics in its diagnosis. Methods Relevant articles were searched through 2 online databases (PubMed and Web of Science) from January 2000 to March 2022. The metabolites involved were systematically examined and compared. Pathway analysis was conducted through the online software MetaboAnalyst 5.0. Results A total of 14 papers reporting 212 metabolites were included in this study. There were several highly reported metabolites: bile acids, such as glycocholic acid, taurochenodeoxycholic acid, taurocholic acid, tauroursodeoxycholic acid, and glycochenodeoxycholic acid. Dysregulation of metabolic pathways involved bile acid metabolism and lipid metabolism. Metabolites related to lipid metabolism include phosphatidylcholine, phosphorylcholine, phosphatidylserine, sphingomyelin, and ceramide. Conclusions This study provides a systematic review of metabolomics of ICP and deepens our understanding of the etiology of ICP.
引用
收藏
页数：15
相关论文
共 47 条
[1]   Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy [J].
Chen, Jianbo ;
Deng, Wenping ;
Wang, Junwei ;
Shao, Yong ;
Ou, Minglin ;
Ding, Min .
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2013, 122 (01) :5-8
[2]   The urinary bile acid profiling analysis of asymptomatic hypercholanemia of pregnancy: A pseudo-targeted metabolomics study [J].
Chen, Xiao ;
Zhang, Xiaoqing ;
Xu, Biao ;
Cui, Yue ;
He, Yifan ;
Yang, Ting ;
Shao, Yong ;
Ding, Min .
CLINICA CHIMICA ACTA, 2019, 497 :67-75
[3]   Bile Acid Metabolism and Signaling [J].
Chiang, John Y. L. .
COMPREHENSIVE PHYSIOLOGY, 2013, 3 (03) :1191-1212
[4]   Diagnostic and therapeutic profiles of serum bile acids in women with intrahepatic cholestasis of pregnancy-a pseudo-targeted metabolomics study [J].
Cui, Yue ;
Xu, Biao ;
Zhang, Xiaoqing ;
He, Yifan ;
Shao, Yong ;
Ding, Min .
CLINICA CHIMICA ACTA, 2018, 483 :135-141
[5]   Plasma lipid profiles of women with intrahepatic cholestasis of pregnancy [J].
Dann, AT ;
Kenyon, AP ;
Wierzbicki, AS ;
Seed, PT ;
Shennan, AH ;
Tribe, RM .
OBSTETRICS AND GYNECOLOGY, 2006, 107 (01) :106-114
[6]   Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy [J].
de Seymour, Jamie V. ;
Tu, Stephanie ;
He, Xiaoling ;
Zhang, Hua ;
Han, Ting-Li ;
Baker, Philip N. ;
Sulek, Karolina .
METABOLOMICS, 2018, 14 (06)
[7]   Bile Acid Physiology [J].
Di Ciaula, Agostino ;
Garruti, Gabriella ;
Baccetto, Raquel Lunardi ;
Molina-Molina, Emilio ;
Bonfrate, Leonilde ;
Wang, David Q. -H. ;
Portincasa, Piero .
ANNALS OF HEPATOLOGY, 2017, 16 :S4-S14
[8]   Studies on Novel Diagnostic and Predictive Biomarkers of Intrahepatic Cholestasis of Pregnancy Through Metabolomics and Proteomics [J].
Dong, Ruirui ;
Ye, Ningzhen ;
Zhao, Shaojie ;
Wang, Gaoying ;
Zhang, Yan ;
Wang, Tiejun ;
Zou, Ping ;
Wang, Jing ;
Yao, Tingting ;
Chen, Minjian ;
Zhou, Conghua ;
Zhang, Ting ;
Luo, Liang .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[9]   Low phospholipid-associated cholestasis and cholelithiasis [J].
Erlinger, Serge .
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2012, 36 :S36-S40
[10]   Intrahepatic cholestasis of pregnancy: new insights into its pathogenesis [J].
Floreani, Annarosa ;
Caroli, Diego ;
Lazzari, Roberta ;
Memmo, Alessia ;
Vidali, Elisa ;
Colavito, Davide ;
D'Arrigo, Antonello ;
Leon, Alberta ;
Romero, Roberto ;
Gervasi, Maria Teresa .
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2013, 26 (14) :1410-1415
12345