Negative feedback loop between ZBTB7A and TGF-β in breast cancer

被引：10
作者：
Shen, Yingying [1 ]
Cao, Renxian [1 ,2 ]
Liu, Wen [2 ]
Zhou, Yuqing [2 ]
Wu, Ying [1 ]
Tan, Jingjing [2 ]
Jin, Min [2 ]
Zhong, Jing [1 ]
Zhang, Qinghai [1 ]
Liu, Jianghua [1 ,2 ]
Zu, Xuyu [1 ]
机构：
[1] Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China
[2] Univ South China, Affiliated Hosp 1, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China
来源：
ONCOLOGY LETTERS | 2017年 / 14卷 / 02期
基金：
中国国家自然科学基金;
关键词：
zinc finger and BTB domain containing 7A; transforming growth factor-beta 1; breast cancer; negative feedback; metastasis; TO-MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR; POKEMON; PROTOONCOGENE; EXPRESSION; REPRESSION; PATHWAY; CELLS; DIFFERENTIATION; IDENTIFICATION;
D O I：
10.3892/ol.2017.6291
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Zinc finger and BTB domain containing 7A (ZBTB7A) is aberrantly expressed in breast cancer, but the involvement of ZBTB7A in breast cancer remains controversial. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine which promotes breast cancer metastasis. ZBTB7A and TGF-beta are important factors in tumor development. However, the association between ZBTB7A and TGF-beta in breast cancer remains unknown. The results of the present study revealed that TGF-beta 1 induced the expression of ZBTB7A via the phosphoinositide 3-kinase-protein kinase B signaling pathway in human breast cancer cells, and ZBTB7A inhibited the expression of TGF-beta 1 through indirectly suppressing the promoter activity of TGF-beta 1. Furthermore, no significant correlation between the expression of ZBTB7A and TGF-beta 1 were identified in breast cancer tissues using tissue microarray assay and human cancer genomics analysis. These results have identified a negative feedback loop between ZBTB7A and TGF-beta signaling, suggesting ZBTB7A as a potential modulator of breast cancer metastasis. Thus, the results of the present study suggested that ZBTB7A is a potential prognostic biomarker for breast cancer.
引用
收藏
页码：1403 / 1410
页数：8
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