RETRACTED: SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling (Retracted article. See vol. 49, 2023)

被引：45
|
作者：
Wang, Hanning [1 ]
Liu, Hao [2 ]
Chen, Kaiyun [1 ]
Xiao, Jinfeng [1 ]
He, Ke [1 ]
Zhang, Jinqian [3 ]
Xiang, Guoan [1 ]
机构：
[1] Second Peoples Hosp Guangdong Prov, Dept Gen Surg, Guangzhou 510317, Guangdong, Peoples R China
[2] So Med Univ, Dept Gen Surg, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China
[3] Capital Med Univ, Inst Infect Dis, Beijing Ditan Hosp, Beijing 100015, Peoples R China
来源：
ONCOLOGY REPORTS | 2012年 / 28卷 / 01期
基金：
中国国家自然科学基金;
关键词：
hepatocellular carcinoma; SIRT1; PI3K/PTEN/AKT; tumorigenesis; MAMMALIAN SIRTUINS; LIFE-SPAN; CANCER; EXPRESSION; PROTEIN; NAD; METABOLISM; EXTENSION; SURVIVAL; P53;
D O I：
10.3892/or.2012.1788
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
SIRT1 is the human orthologue of SIR2, a conserved NAD-dependent protein deacetylase that regulates longevity in yeast and in Caenorhabditis elegans. Overexpression of SIRT1 in cancer tissue, compared with normal tissue, has been demonstrated, suggesting that SIRT1 may act as a tumor promoter. The function of SIRT1 in liver cancer has not been elucidated. In the present study, SIRT1 re-expression or knockdown was induced in hepatoma cell lines and liver normal cell lines. Our study demonstrated that overexpression of SIRT1 promoted mitotic entry of liver cells, cell growth and proliferation and inhibited apoptosis. The apoptosis involved caspase-3 and caspase-7, and was related to the PTEN/PI3K/AKT signaling pathway. The results demonstrate that SIRT1 promotes tumorigenesis of hepatocellular carcinoma (HCC) through the PTEN/PI3K/AKT signaling pathway. SIRT1 may serve as a novel target for selective killing of cancer versus normal liver cells.
引用
收藏
页码：311 / 318
页数：8
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