Antimalarial Activity of Pyrroloiminoquinones from the Australian Marine Sponge Zyzzya sp.

被引：65

作者：

Davis, Rohan A. ^{[1
]}

Buchanan, Malcolm S. ^{[1
]}

Duffy, Sandra ^{[1
]}

Avery, Vicky M. ^{[1
]}

Charman, Susan A. ^{[2
]}

Charman, William N. ^{[2
]}

White, Karen L. ^{[2
]}

Shackleford, David M. ^{[2
]}

Edstein, Michael D. ^{[3
]}

Andrews, Katherine T. ^{[1
]}

Camp, David ^{[1
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Monash Univ, Ct Drug Candidate Optimisat, Parkville, Vic 3052, Australia

[3] Australian Army Malaria Inst, Brisbane, Qld 4051, Australia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷 / 12期

基金：

澳大利亚研究理事会;

关键词：

PLASMODIUM-FALCIPARUM MALARIA; WATER CARIBBEAN SPONGE; NATURAL-PRODUCTS; PYRROLOQUINOLINE ALKALOIDS; DRUG DISCOVERY; CYTOTOXIC PYRROLOIMINOQUINONES; BIOSYNTHETIC-ENZYMES; THERAPEUTIC TARGETS; GENUS LATRUNCULIA; DISCORHABDIN-C;

D O I：

10.1021/jm3002795

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new bispyrroloiminoquinone alkaloid, tsitsikammamine C (1), displayed potent in vitro antimalarial activity with IC50 values of 13 and 18 nM against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum, respectively. Tsitsikammamine C (1) displayed selectivity indices of >200 against HEK293 cells and inhibited both ring and trophozoite stages of the malaria parasite life cycle. Previously reported compounds makaluvamines J (2), G (3), L (4), K (5) and damirones A (6) and B (7) were also isolated from the same marine sponge (Zyzzya sp.). Compounds 2-4 displayed potent growth inhibitory activity (IC50 < 100 nM) against both P. falciparum lines and only moderate c-ytotoxicity against HEK293 cells (IC50 = 1-4 mu M). Makaluvamine G (3) was not toxic to mice and suppressed parasite growth in P. berghei infected mice following subcutaneous administration at 8 mg kg(-1) day(-1).

引用

页码：5851 / 5858

页数：8

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