Association of endometriosis risk and genetic polymorphisms involving biosynthesis of sex steroids and their receptors: an updating meta-analysis

被引:23
作者
Hu, Xueying [1 ]
Zhou, Yang [1 ]
Feng, Qiming [1 ]
Wang, Rensheng [2 ]
Su, Li [1 ]
Long, Jianxiong [1 ]
Wei, Bo [1 ]
机构
[1] Guangxi Med Univ, Sch Publ Hlth, Nanning 530021, Guangxi Zhuang, Peoples R China
[2] Guangxi Med Univ, Affiliated Hosp 1, Dept Radiotherapy, Nanning 530021, Guangxi Zhuang, Peoples R China
关键词
CYP17; ER; PR; HSD17B1; CYP19; Endometriosis; Meta-analysis; GENOME-WIDE ASSOCIATION; PROGESTERONE-RECEPTOR; BETA-GENE; CYP19; GENE; NO ASSOCIATION; ER-BETA; ALPHA; WOMEN; INFERTILITY; PROGINS;
D O I
10.1016/j.ejogrb.2012.05.008
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The objective of our study is to assess the association of endometriosis risk and genetic polymorphisms involving biosynthesis of sex steroids and their receptors. A systematic search of three databases was conducted. Twenty-seven studies on the association of the cytochrome P450 subfamily 17 (CYP17), estrogen receptor gene (ER), progesterone receptor gene (PR), 17-beta-hydroxysteroid dehydrogenase type 1 gene (HSD17B1), and cytochrome P450 subfamily 19 (CYP19)polymorphisms with endometriosis risk were identified. When all groups were pooled, we found an association between HSD17B1 (A variant allele vs. G wild allele: odds ratio (OR) = 1.42,95% confidence interval (CI) = 1.10-1.84, P = 0.007) and PR (P2 variant allele vs. P1 wild allele, OR = 1.43, 95% CI = 0.99-2.08, P = 0.058) polymorphisms and endometriosis risk, while failing to detect links with CYP17, ER, and CYP19 polymorphisms examined. In the subgroup analysis, a significant association of CYP17 and ER alpha-Pvull polymorphisms with endometriosis was found neither in a Caucasian population nor in an Asian population. The findings of our study suggest that HSD17B1 and PR polymorphisms are associated with an increased risk of endometriosis. Further investigation into the association between CYP17, ER, PR, HSD17B1, and CYP19 polymorphisms and endometriosis risk is warranted and should include larger sample sizes. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1 / 9
页数:9
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