Cytotoxic polyacetylenes from the marine sponge Petrosia sp.

被引：56

作者：

Kim, JS

Lim, YJ

Im, KS

Jung, JH ^{[1
]}

Shim, CJ

Lee, CO

Hong, J

Lee, H

机构：

[1] Pusan Natl Univ, Coll Pharm, Res Inst Drug Dev, Pusan 609735, South Korea

[2] Han Nam Univ, Dept Biol, Taejon, South Korea

[3] Korea Res Inst Chem Technol, Pharmaceut Screening Ctr, Taejon 305606, South Korea

[4] Korea Basic Sci Inst, Mass Spectrometry Grp, Taejon, South Korea

[5] Korean Ocean Res & Dev Inst, Seoul, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 04期

关键词：

D O I：

10.1021/np9803427

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three C-46 (1--3) and three C-30 (4-6) polyacetylenic alcohols with cytotoxic activity against a small panel of human solid-tumor cell lines have been isolated from the marine sponge Petrosia sp. Although compound 1 was identified as the stereoisomer of petrocortyne A, the structures of compounds 2-5 have not been previously reported and were established by spectral methods. Compound 6 was identified as the known compound petrosiacetylene D. The stereochemistry of compounds 1-5 was determined by the modified Mosher's method.

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页码：554 / 559

页数：6

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