Air Pollution Exposure During Pregnancy, Ultrasound Measures of Fetal Growth, and Adverse Birth Outcomes: A Prospective Cohort Study

被引：150

作者：

van den Hooven, Edith H. ^{[1
,2
,3
]}

Pierik, Frank H. ^{[2
]}

de Kluizenaar, Yvonne ^{[2
]}

Willemsen, Sten P. ^{[3
,4
]}

Hofman, Albert ^{[3
]}

van Ratingen, Sjoerd W. ^{[2
]}

Zandveld, Peter Y. J. ^{[2
]}

Mackenbach, Johan P. ^{[5
]}

Steegers, Eric A. P. ^{[6
]}

Miedema, Henk M. E. ^{[2
]}

Jaddoe, Vincent W. V. ^{[1
,3
,7
]}

机构：

[1] Erasmus MC, Generat Study Grp R, NL-3000 CA Rotterdam, Netherlands

[2] TNO, Utrecht, Netherlands

[3] Erasmus MC, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

[4] Erasmus MC, Dept Biostat, NL-3000 CA Rotterdam, Netherlands

[5] Erasmus MC, Dept Publ Hlth, NL-3000 CA Rotterdam, Netherlands

[6] Erasmus MC, Dept Obstet & Gynaecol, NL-3000 CA Rotterdam, Netherlands

[7] Erasmus MC, Dept Paediat, NL-3000 CA Rotterdam, Netherlands

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2012年 / 120卷 / 01期

关键词：

air pollution; birth weight; dispersion modeling; fetal growth; intrauterine growth restriction; nitrogen dioxide; particulate matter; pregnancy; preterm birth; PARTICULATE MATTER; GESTATIONAL-AGE; WEIGHT; DELIVERY; HEALTH; RISK; HEAD;

D O I：

10.1289/ehp.1003316

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

BACKGROUND: Air pollution exposure during pregnancy might have trimester-specific effects on fetal growth. OBJECTIVE: We prospectively evaluated the associations of maternal air pollution exposure with fetal growth characteristics and adverse birth outcomes in 7,772 subjects in the Netherlands. METHODS: Particulate matter with an aerodynamic diameter < 10 mu m (PM10) and nitrogen dioxide (NO2) levels were estimated using dispersion modeling at the home address. Fetal head circumference, length, and weight were estimated in each trimester by ultrasound. Information on birth outcomes was obtained from medical records. RESULTS: In cross-sectional analyses, NO2 levels were inversely associated with fetal femur length in the second and third trimester, and PM10 and NO2 levels both were associated with smaller fetal head circumference in the third trimester [-0.18 mm, 95% confidence interval (Cl): -0.24, -0.12 mm; and -0.12 mm, 95% CI: -0.17, -0.06 mm per 1-mu g/m(3) increase in PM10 and NO2, respectively]. Average PM10 and NO2 levels during pregnancy were not associated with head circumference and length at birth or neonatally, but were inversely associated with birth weight (-3.6 g, 95% CI: -6.7, -0.4 g; and -3.4 g, 95% Cl: -6.2, -0.6 g, respectively). Longitudinal analyses showed similar patterns for head circumference and weight, but no associations with length. The third and fourth quartiles of PM10 exposure were associated with preterm birth [odds ratio (OR) = 1.40, 95% Cl: 1.03, 1.89; and OR = 1.32; 95% CI: 0.96, 1.79, relative to the first quartile]. The third quartile of PM10 exposure, but not the fourth, was associated with small size for gestational age at birth (SGA) (OR = 1.38; 95% CI: 1.00, 1.90). No consistent associations were observed for NO2 levels and adverse birth outcomes. CONCLUSIONS: Results suggest that maternal air pollution exposure is inversely associated with fetal growth during the second and third trimester and with weight at birth. PM10 exposure was positively associated with preterm birth and SGA.

引用

页码：150 / 156

页数：7

共 37 条

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